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Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth

Date:
March 11, 2009
Source:
Journal of Clinical Investigation
Summary:
New research indicates that overexpression of the transcription factor SOX9 restores the sensitivity of mouse and human melanomas to the anticancer agent retinoic acid, thereby stopping tumor growth. The authors suggest that a combined therapeutic strategy, increasing the expression of SOX9 while simultaneously treating with RA, may provide new hope to effectively treat RA-resistant cancers such as melanoma.

Melanomas are often resistant to standard cancer therapies such as radiotherapy, chemotherapy, and retinoic acid (RA).

Given the lack of available treatments for melanoma, the prognosis for patients is often poor.

However, Vincent Hearing and colleagues at the National Cancer Institute at the National Institutes of Health in Bethesda, Maryland, have now found a way to restore the sensitivity of melanomas to RA, suggesting that this noncytotoxic therapeutic approach may be a viable option for melanoma treatment.

Overexpression of SOX9, a transcription factor, not only restored RA sensitivity of mouse and human melanomas, but remarkably stopped tumor growth.

The authors suggest that a combined therapeutic strategy, increasing the expression of SOX9 while simultaneously treating with RA, may provide new hope to effectively treat RA-resistant cancers such as melanoma.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Passeron et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI34015

Cite This Page:

Journal of Clinical Investigation. "Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth." ScienceDaily. ScienceDaily, 11 March 2009. <www.sciencedaily.com/releases/2009/03/090309191501.htm>.
Journal of Clinical Investigation. (2009, March 11). Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/03/090309191501.htm
Journal of Clinical Investigation. "Transcriptional Factor SOX9 Renders Melanomas Sensitive To Retinoic Acid And Stops Tumor Growth." ScienceDaily. www.sciencedaily.com/releases/2009/03/090309191501.htm (accessed October 1, 2014).

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