Featured Research

from universities, journals, and other organizations

Stem Cell Administration Study Demonstrates Improved Quality Of Life For Patients Suffering From Spinal Cord Injury

Date:
March 28, 2009
Source:
DaVinci Biosciences
Summary:
Scientists are reporting the safety and feasibility of a new acute and chronic spinal cord injury treatment platform. Their study demonstrates that administering adult autologous bone marrow derived stem cells via multiple routes is feasible, safe, and most importantly, improves the quality of life for both acute and chronic spinal cord injury patients.

DaVinci Biosciences, in collaboration with Luis Vernaza Hospital in Ecuador, have announced the publication of study results demonstrating the safety and feasibility of its acute and chronic spinal cord injury treatment platform in Cell Transplantation, a peer-reviewed journal focused on regenerative medicine. The study demonstrates that administering adult autologous bone marrow derived stem cells via multiple routes is feasible, safe, and most importantly, improves the quality of life for both acute and chronic spinal cord injury (SCI) patients.

Related Articles


The study documents eight patients (four acute and four chronic) who were administered autologous bone marrow derived stem cells using a multiple route delivery technique. A two-year follow-up was performed on all the patients in the study who received the treatment. Using sequential MRIs, the follow-up demonstrated noticeable morphological changes within the spinal cord after administration of autologous bone marrow derived stem cells. Participating spinal cord injury patients experienced varying degrees of improvement in their quality of life, such as increased bladder control, regained mobility and sensation. Most importantly, the study demonstrated no adverse effects such as tumor formation, increased pain, and/or deterioration of function following administration of autologous bone marrow derived stem cells. In a video provided by the Luis Vernaza Hospital, patients involved in the study can be seen discussing their improved quality of life at: http://bit.ly/DavinciStemCellStudy.

Up to 400,000 people in the United States are estimated to live with spinal cord injuries, according to the Christopher and Dana Reeve Foundation. On January 23, 2009, The Food and Drug Administration approved the first U.S. clinical trial to use human embryonic stem cells in paralyzed humans. In a recent ABC News story on this FDA approval, Dr. Sean Morrison, director at the University of Michigan Center for Stem Cell Biology was cited as saying that even if this study could restore partial spinal cord function or bladder function that it would be a really important advancement. The study published by DaVinci Biosciences and Luis Vernaza Hospital in Cell Transplantation, which used stem cells derived from the patient’s own bone marrow, documents the restoration of significant movement, sensation, and bladder function in patients suffering from a spinal cord injury.

“This collaborative study with the Luis Vernaza Hospital is a significant milestone for patients suffering from spinal cord injury,” said Dr. Rafael Gonzalez, Director of Research and Development for DaVinci Biosciences. “We are pleased to see the publication of our research; it represents a giant step in the process of improving the quality of life in people living with spinal cord injury and other neurodegenerative disorders.”

“The outcome of this study is exciting for us and our patients; we plan on expanding and building upon the results,” said Francisco Silva, President of DaVinci Biosciences. “We strongly believe that this an important first step for realizing the therapeutic application of stem cells for treating diseases and injuries such as spinal cord injury in humans."

“Although there have been numerous studies in animals demonstrating the benefits of stem cell treatment for the treatment of spinal cord injury, this is the first published study of its kind, it gives patients the possibility that their quality of life can be improved,” said Dr. Paul Sanberg, Director of the Center of Excellence for Aging and Brain Repair at the University of South Florida. A survey of spinal cord injury patients conducted in 2004 illustrates that one of the most important aspects in improving their quality of life would be the ability to control bladder function. Patients involved in DaVinci Biosciences’ study regained partial or full bladder function, bladder sensation and/or the active ability to void.

DaVinci Biosciences is currently developing cell-based therapeutics and small molecule compounds for the treatment and cure of paralysis caused by spinal cord injury, amyotrophic lateral sclerosis (ALS) and other human degenerative disorders. In tandem with the Company’s advances in cell-based and small molecule therapies, DaVinci Biosciences along with its collaborator has patented a surgical technique for the effective delivery of therapies directly into the spinal cord.


Story Source:

The above story is based on materials provided by DaVinci Biosciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Geffner, L. F.; Santacruz, P.; Izurieta, M.; Flor, L.; Maldonado, B.; Auad, A. H.; Montenegro, X.; Gonzalez, R.; Silva, F. Administration of Autologous Bone Marrow Stem Cells Into Spinal Cord Injury Patients Via Multiple Routes Is Safe and Improves Their Quality of Life: Comprehensive Case Studies. Cell Transplantation, 2008; 17 (12): 1277 DOI: 10.3727/096368908787648074

Cite This Page:

DaVinci Biosciences. "Stem Cell Administration Study Demonstrates Improved Quality Of Life For Patients Suffering From Spinal Cord Injury." ScienceDaily. ScienceDaily, 28 March 2009. <www.sciencedaily.com/releases/2009/03/090312130650.htm>.
DaVinci Biosciences. (2009, March 28). Stem Cell Administration Study Demonstrates Improved Quality Of Life For Patients Suffering From Spinal Cord Injury. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/03/090312130650.htm
DaVinci Biosciences. "Stem Cell Administration Study Demonstrates Improved Quality Of Life For Patients Suffering From Spinal Cord Injury." ScienceDaily. www.sciencedaily.com/releases/2009/03/090312130650.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins