Featured Research

from universities, journals, and other organizations

Obesity Associated With Worse Outcomes After Pancreatic Cancer Surgery

Date:
March 23, 2009
Source:
JAMA and Archives Journals
Summary:
Obese patients with a body mass index of more than 35 appear more likely to have cancer that has spread to their lymph nodes, lower rates of survival and higher rates of recurrence following surgery for pancreatic cancer, according to a new report.

Obese patients with a body mass index (BMI) of more than 35 appear more likely to have cancer that has spread to their lymph nodes, lower rates of survival and higher rates of recurrence following surgery for pancreatic cancer, according to a new report.

Obesity rates have dramatically increased in the United States over the past 20 years, according to background information in the article. "In many obesity-related diseases and malignant neoplasms [cancerous tumors], an increased prevalence of pancreatic cancer has been reported in numerous epidemiologic and cohort studies focusing on obese patients," the authors write. "Further, obesity has been associated with decreased survival in patients with pancreatic adenocarcinoma, although the mechanism remains unknown."

Jason B. Fleming, M.D., of The University of Texas M. D. Anderson Cancer Center, Houston, and colleagues studied 285 consecutive patients who underwent pancreatic resection (removal of some or all of the pancreas) to treat pancreatic cancer between 1999 and 2006. Data about surgery, patient BMI and outcomes were obtained from the institutional database and electronic medical records.

A total of 152 patients (53 percent) died during a median (midpoint) of 16 months of follow-up. Patients with a BMI higher than 35 survived a median of 13.2 months, compared with 27.4 months for those with a BMI of less than 23. At the last follow-up, 15 of 20 patients (75 percent) with a BMI of more than 35 had died, compared with 137 of 265 patients (52 percent) with a BMI of 35 or less.

"We identified a subset of obese patients (BMI greater than 35) who were at 12-fold risk of lymph node metastasis compared with non-obese patients (BMI of 35 or less). The estimated disease-free and overall survival rates were decreased in the obese patients, and the risk of cancer recurrence and death after pancreatectomy [removal of the pancreas] was nearly twice that in non-obese patients," the authors write. "Cancer recurrence was observed in 95 percent (19 of 20) of patients in the group with a BMI of more than 35 vs. 61 percent (161 of 264) of all other patients."

Previous studies have shown an association between a BMI of more than 35 and an increased risk of death from pancreatic cancer, the authors note. "Our findings extend these observations to those patients who undergo surgery to treat pancreatic cancer and suggest that obesity is a host factor affecting tumor biology independent of the difficulties (patient- and treatment-related) involved in delivering oncologic care in obese patients. Future investigations should include a search for systemic or tumor biomarkers in this group of patients that could provide additional insight."

This study was supported by the Various Donor Fund for Pancreatic Cancer Research and by a grant to the University of Texas M.D. Anderson Cancer Center from the National Institutes of Health.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fleming et al. Influence of Obesity on Cancer-Related Outcomes After Pancreatectomy to Treat Pancreatic Adenocarcinoma. Archives of Surgery, 2009; 144 (3): 216 DOI: 10.1001/archsurg.2008.580

Cite This Page:

JAMA and Archives Journals. "Obesity Associated With Worse Outcomes After Pancreatic Cancer Surgery." ScienceDaily. ScienceDaily, 23 March 2009. <www.sciencedaily.com/releases/2009/03/090316173315.htm>.
JAMA and Archives Journals. (2009, March 23). Obesity Associated With Worse Outcomes After Pancreatic Cancer Surgery. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/03/090316173315.htm
JAMA and Archives Journals. "Obesity Associated With Worse Outcomes After Pancreatic Cancer Surgery." ScienceDaily. www.sciencedaily.com/releases/2009/03/090316173315.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins