Featured Research

from universities, journals, and other organizations

Steroid Nasal Wash Appears To Improve Health Of Patients With Chronic Rhinosinusitis

Date:
March 23, 2009
Source:
JAMA and Archives Journals
Summary:
A nasal wash containing the corticosteroid budesonide appears to reduce symptoms of chronic rhinosinusitis without suppressing the function of the adrenal glands, a known complication of this type of drug that would indicate absorption throughout the whole body, according to a new report.

A nasal wash containing the corticosteroid budesonide appears to reduce symptoms of chronic rhinosinusitis without suppressing the function of the adrenal glands, a known complication of this type of drug that would indicate absorption throughout the whole body, according to a new report.

Chronic rhinosinusitis—a persistent inflammation of the nose and sinuses behind the nose—affects up to 14 percent of the U.S. population, according to background information in the article. An aqueous nasal spray containing budesonide has been shown to be safe and have a benefit for those with chronic rhinosinusitis and recurring allergies. The medication is also available in respules—small, plastic liquid-containing devices that can be opened and mixed with saline to produce a nasal wash. According to the authors, no previous studies have been conducted to demonstrate the safety of such a preparation.

Neil S. Sachanandani, B.S., and colleagues at the Washington University School of Medicine, St. Louis, assessed the effects of budesonide on adrenal function in nine patients between 2005 and 2006. Participants were instructed to use a nasal wash composed of 0.25 milligrams of budesonide and 5 milliliters of saline in each nostril once daily for 30 days. At clinic visits before and after the treatment period, participants completed a questionnaire assessing their rhinosinusitis symptoms and related quality of life. Their cortisol levels were measured after injection with cosyntropin, a compound that stimulates the release of cortisol by the adrenal glands—a standard method of testing adrenal function.

All patients showed an adequate adrenal response to cosyntropin before and after budesonide therapy, the authors report. Total scores on the questionnaire assessing symptoms improved clinically and statistically following therapy. All patients "reported some form of overall improvement with the use of budesonide, and six of the nine patients (67 percent) would recommend this drug to a friend," the authors write.

"The clinical significance of this study is that budesonide nasal respules appear safe for short-term use for the relief of symptoms associated with chronic sinusitis," they continue. "Budesonide respules seem to provide an effective treatment option for the patient with chronic rhinosinusitis with minimal fear of systemic adverse effects."

The Food and Drug Administration has not approved the use of budesonide as a nasal wash, so therefore this preparation would be an off-label use, they note. Clinicians should discuss the risks associated with the use of the product. Decreased bone mineral density is one potential complication of long-term use and deserves further study, the authors conclude.

This research was supported, in part, by a grant from the National Institutes of Health Roadmap Predoctoral Clinical Research Training Program and the Washington University General Clinical Research Center.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sachanandani et al. The Effect of Nasally Administered Budesonide Respules on Adrenal Cortex Function in Patients With Chronic Rhinosinusitis. Archives of Otolaryngology - Head and Neck Surgery, 2009; 135 (3): 303 DOI: 10.1001/archoto.2008.555

Cite This Page:

JAMA and Archives Journals. "Steroid Nasal Wash Appears To Improve Health Of Patients With Chronic Rhinosinusitis." ScienceDaily. ScienceDaily, 23 March 2009. <www.sciencedaily.com/releases/2009/03/090316173325.htm>.
JAMA and Archives Journals. (2009, March 23). Steroid Nasal Wash Appears To Improve Health Of Patients With Chronic Rhinosinusitis. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/03/090316173325.htm
JAMA and Archives Journals. "Steroid Nasal Wash Appears To Improve Health Of Patients With Chronic Rhinosinusitis." ScienceDaily. www.sciencedaily.com/releases/2009/03/090316173325.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins