Featured Research

from universities, journals, and other organizations

Cancerous or Benign? Liver Cell Adenoma Or Hepatocellular Carcinoma?

Date:
March 20, 2009
Source:
World Journal of Gastroenterology
Summary:
Liver cell adenoma (LCA) is a benign tumor of the liver parenchyma that is associated with the use of oral contraceptives or with glycogen-storage disease. A group in Japan reported a case of LCA found in a 40-year-old woman without a history of oral contraceptive use in which the sequential alteration of the radiological findings suggested well-differentiated hepatocellular carcinoma.

Liver cell adenoma (LCA) is a benign tumor of the liver parenchyma that is associated with the use of oral contraceptives or with glycogen-storage disease. A group in Japan reported a case of LCA found in a 40-year-old woman without a history of oral contraceptive use in which the sequential alteration of the radiological findings suggested well-differentiated hepatocellular carcinoma.

Related Articles


Recently, LCAs with typical backgrounds of the patients are diagnosed by radiological findings without pathological findings due to the progress of diagnostic imaging techniques. A typical LCA shows low density or isodensity on plain computed tomography, presents a homogenous contrasting effect on arterial phase and does not show an apparent wash out on delayed phase. A typical LCA in magnetic resonance imaging shows almost the same signal intensity as the surrounding parenchyma on T1 and T2 and shows high intensity on fat suppression T2.

However, LCA often presents difficulties in a differential diagnosis with well-differentiated HCC, especially without the typical backgrounds of the patients.

A research article to be published on March 14, 2009 in the World Journal of Gastroenterology reports an extremely rare case of LCA. The research team led by Prof. Shimosegawa from the Division of Gastroenterology, Tohoku University reported a case of LCA found in a 40-year-old woman without a typical history in which the sequential alteration of the radiological findings suggested well-differentiated HCC.

A liver tumor 35 mm in diameter was found incidentally in a woman, which showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed phase of CT. The tumor was found to contain fat on MRI. However, radiological findings altered, which caused to suspect that a well-differentiated HCC containing fat was becoming dedifferentiated. Partial hepatectomy was performed and the pathological findings showed the typical findings of LCA. Diagnosis of LCA only by radiological findings is difficult in patients without backgrounds such as a history of receiving contraceptives or glycogen-storage disease.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kogure et al. Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma. World Journal of Gastroenterology, 2009; 15 (10): 1267 DOI: 10.3748/wjg.15.1267

Cite This Page:

World Journal of Gastroenterology. "Cancerous or Benign? Liver Cell Adenoma Or Hepatocellular Carcinoma?." ScienceDaily. ScienceDaily, 20 March 2009. <www.sciencedaily.com/releases/2009/03/090320102132.htm>.
World Journal of Gastroenterology. (2009, March 20). Cancerous or Benign? Liver Cell Adenoma Or Hepatocellular Carcinoma?. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2009/03/090320102132.htm
World Journal of Gastroenterology. "Cancerous or Benign? Liver Cell Adenoma Or Hepatocellular Carcinoma?." ScienceDaily. www.sciencedaily.com/releases/2009/03/090320102132.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins