Featured Research

from universities, journals, and other organizations

Human Papillomavirus Genotype Distribution In New Mexico Cervical Cancers

Date:
March 24, 2009
Source:
Journal of the National Cancer Institute
Summary:
DNA from human papilloma virus type 16 and HPV type 18 were found in the majority of invasive cervical cancers in New Mexico in the 1980s and 1990s, according to a new population-based study.

DNA from human papilloma virus type 16 (HPV16) and HPV type 18 (HPV18) were found in the majority of invasive cervical cancers in New Mexico in the 1980s and 1990s, according to a population-based study published in the March 24 online issue of the Journal of the National Cancer Institute.

The mean age of women diagnosed with HPV16- or HPV18-positive cancer was 5 years younger than that of women diagnosed with cancers associated with other HPV types, which may have implications for cancer screening in the future.

Large population-based studies that examine HPV genotype distribution in the United States have been lacking. Such studies are necessary to assess the impact of HPV vaccines that aim to reduce the incidence of cervical cancer due to HPV16 and HPV18.

In the current study, Cosette M. Wheeler, Ph.D., of the University of New Mexico Health Sciences Center in Albuquerque, and colleagues used the Surveillance, Epidemiology, and End Results registry to identify 1,213 cases of in situ cervical cancer diagnosed between 1985 and 1999 and 808 cases of invasive cervical cancer diagnosed between 1980 and 1999 in New Mexico. The investigators used DNA-based testing to identify the HPV genotype that was present in tumor samples. In addition, they tested 4,007 cervical Pap test specimens from women who did not have cancer for the presence of HPV DNA.

HPV16 DNA was found in 53.2 percent of invasive cervical cancers, while HPV18 DNA was found in 13.1 percent, and HPV45 DNA in 6.1 percent. In the in situ cervical cancer samples, HPV16 DNA was detected in 56.3 percent of cases, HPV31 DNA in 12.6 percent, and HPV33 DNA in 8.0 percent. The median age at diagnosis of invasive cancer positive for HPV16 and HPV18 was 48.1 and 45.9 years, respectively. By contrast, the median age at diagnosis of invasive cancer positive for other HPV genotypes was 52.3 years.

"To our knowledge, this is the largest study of this kind conducted in a U.S. population," the authors write. "This study of HPV genotypes in New Mexico provides important baseline data for evaluating the effectiveness of newly implemented HPV-based technologies, HPV vaccines, and HPV screening in the prevention of cervical cancer. Moreover, these data can guide the future application of these technologies to maximize the cost-effec¬tive, public health benefits of these interventions."

The newly approved HPV vaccine protects against infections due to HPV16 and HPV18, which are associated with an earlier cancer diagnosis than other HPV genotypes. The authors suggest, therefore, that cervical cancer screening might safely be delayed, once the vaccine is more widely used, until women reach the age of 25. This possibility is further supported by the fact that very few women under age of 25 are diagnosed with cervical cancer.

In an accompanying editorial, Lauri E. Markowitz, M.D., of the Centers for Disease Control and Prevention in Atlanta, and colleagues describe some of the challenges the scientific and public health communities face in evaluating the impact of HPV vaccines. They also discuss issues related to cervical cancer screening and changing screening guidelines for vaccinated populations.

The work by Wheeler and colleagues provides important baseline data and raises numerous issues that must be considered, according to the editorialists. They conclude that "continued work is needed to determine the best methods for monitoring vaccine impact and optimal strategies for both primary and secondary prevention of cervical cancer."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal References:

  1. Cosette M. Wheeler, William C. Hunt, Nancy E. Joste, Charles R. Key, Wim G. V. Quint, Philip E. Castle. Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States. J Natl Cancer Inst, 2009; 101: 475-487 DOI: 10.1093/jnci/djn510
  2. Lauri E. Markowitz, Elizabeth R. Unger, and Mona Saraiya. Primary and Secondary Prevention of Cervical Cancer%u2014Opportunities and Challenges. J Natl Cancer Inst, 2009; DOI: 10.1093/jnci/djp044

Cite This Page:

Journal of the National Cancer Institute. "Human Papillomavirus Genotype Distribution In New Mexico Cervical Cancers." ScienceDaily. ScienceDaily, 24 March 2009. <www.sciencedaily.com/releases/2009/03/090324171426.htm>.
Journal of the National Cancer Institute. (2009, March 24). Human Papillomavirus Genotype Distribution In New Mexico Cervical Cancers. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/03/090324171426.htm
Journal of the National Cancer Institute. "Human Papillomavirus Genotype Distribution In New Mexico Cervical Cancers." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324171426.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) — Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins