Featured Research

from universities, journals, and other organizations

'Master Regulator' Of Skin Formation Discovered

Date:
March 25, 2009
Source:
Oregon State University
Summary:
Researchers have found one gene in the human body that appears to be a master regulator for skin development, in research that could help address everything from skin diseases such as eczema or psoriasis to the wrinkling of skin as people age.

Skin from a laboratory mouse that lacks the CTIP2 gene and therefore has incomplete skin development in the bottom image, lacking a protective barrier
Credit: Image courtesy of Oregon State University

Researchers at Oregon State University have found one gene in the human body that appears to be a master regulator for skin development, in research that could help address everything from skin diseases such as eczema or psoriasis to the wrinkling of skin as people age.

Related Articles


Inadequate or loss of expression of this gene, called CTIP2, may play a role in some skin disorders, scientists believe, and understanding the mechanisms of gene action could provide a solution to them.

"We found that CTIP2 is a transcriptional factor that helps control different levels of skin development, including the final phase of a protective barrier formation," said Arup Indra, an OSU assistant professor of pharmacy. "It also seems particularly important in lipid biosynthesis, which is relevant not only to certain skin diseases but also wrinkling and premature skin aging."

The findings of this research, done in collaboration with Mark Leid, OSU professor of pharmacy, were recently published in the Journal of Investigative Dermatology. This work is supported by the National Institutes of Health, which has provided $1.5 million for its continuation.

Skin is actually the largest organ in the human body, and has important functions in protecting people from infection, toxins, microbes and solar radiation. But it's not static – skin cells are constantly dying and being replaced by new cells, to the extent that human skin actually renews its surface layers every three to four weeks. Wrinkles, in fact, are a reflection of slower skin regeneration that occurs naturally with aging.

Major advances have been made in recent years in understanding how skin develops in space and time, and in recent breakthroughs scientists learned how to re-program adult skin cells into embryonic stem cells.

"When you think about therapies for skin disease or to address the effects of skin aging, basically you're trying to find ways to modulate the genetic network within cells and make sure they are doing their job," Indra said. "We now believe that CTIP2 might be the regulator that can do that. The next step will be to find ways to affect its expression."

One of the ways that some ancient botanical extracts or other compounds may accomplish their job in helping to rejuvenate skin, Indra said, is by stimulating gene expression. A more complete understanding of skin genetics might allow that process to be done more scientifically, effectively and permanently.


Story Source:

The above story is based on materials provided by Oregon State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Olga Golonzhka, Xiaobo Liang, Nadia Messaddeq, Jean-Marc Bornert, Adam L Campbell, Daniel Metzger, Pierre Chambon, Gitali Ganguli-Indra, Mark Leid and Arup K Indra. Dual Role of COUP-TF-Interacting Protein 2 in Epidermal Homeostasis and Permeability Barrier Formation. Journal of Investigative Dermatology, 2008; DOI: 10.1038/jid.2008.392

Cite This Page:

Oregon State University. "'Master Regulator' Of Skin Formation Discovered." ScienceDaily. ScienceDaily, 25 March 2009. <www.sciencedaily.com/releases/2009/03/090324171608.htm>.
Oregon State University. (2009, March 25). 'Master Regulator' Of Skin Formation Discovered. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2009/03/090324171608.htm
Oregon State University. "'Master Regulator' Of Skin Formation Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324171608.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins