Featured Research

from universities, journals, and other organizations

Human Cytomegalovirus Stimulates Telomerase Activity In Tissue Culture Cells

Date:
March 24, 2009
Source:
Journal of the National Cancer Institute
Summary:
Infection with human cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal human cells and tumor cells grown in culture.

Infection with human cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal human cells and tumor cells grown in culture.

HCMV has been suspected of causing or promoting cancer, but the mechanism by which the virus acts has been unclear. Several other cancer-related viruses stimulate telomerase activity, which promotes cell proliferation and immortalization.

To learn whether HCMV induces telomerase activity, Dawei Xu, M.D., Ph.D., of the Karolinska Institute in Stockholm, Sweden, and colleagues infected normal diploid fibroblasts and malignant glioma cells with HCMV or introduced a copy of the viral immediate early antigen 72 (IE-72) gene into the cells.

Infection with HCMV induced telomerase expression in both normal and malignant human cells. Introduction of the viral IE-72 gene also induced telomerase activity in both cell types.

"In this study, we reveal a novel mechanism through which HCMV may be linked to or modulate oncogenesis by demonstrating that HCMV stimulates hTERT transcription, thereby activating telomerase, which is essential for the immortalization and transformation of human cells," the authors write.

In an accompanying editorial, Jindrich Cinatl Jr., Ph.D., of the Universität Frankfurt in Germany and colleagues note that they hypothesized previously that HCMV may increase tumor malignancy rather than instigate malignancy. The results by Xu and colleagues may provide important mechanistic insight as to how such a modulatory role could occur.

"…HCMV-induced telomerase activation represents a mechanism that is of possible relevance for both (initiation of) malignant trans¬formation and oncomodulation by HCMV infection," the editorialists write.

The research is published in the March 24 online issue of the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Klas Strååt, Cheng Liu, Afsar Rahbar, Qingjun Zhu, Li Liu, Nina Wolmer-Solberg, Fenglan Lou, Zhaoxu Liu, Jie Shen, Jihui Jia, Satoru Kyo, Magnus Björkholm, Jan Sjöberg, Cecilia Söderberg-Nauclér, and Dawei Xu. Activation of Telomerase by Human Cytomegalovirus. Journal of the National Cancer Institute, 2009; DOI: 0.1093/jnci/djp031

Cite This Page:

Journal of the National Cancer Institute. "Human Cytomegalovirus Stimulates Telomerase Activity In Tissue Culture Cells." ScienceDaily. ScienceDaily, 24 March 2009. <www.sciencedaily.com/releases/2009/03/090324215726.htm>.
Journal of the National Cancer Institute. (2009, March 24). Human Cytomegalovirus Stimulates Telomerase Activity In Tissue Culture Cells. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2009/03/090324215726.htm
Journal of the National Cancer Institute. "Human Cytomegalovirus Stimulates Telomerase Activity In Tissue Culture Cells." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324215726.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins