Featured Research

from universities, journals, and other organizations

How Do Microglia Examine Damaged Synapses?

Date:
April 9, 2009
Source:
National Institute for Physiological Sciences
Summary:
Microglia, immune cells in the brain, are suggested to be involved in the repair of damaged brain. However, it is unknown how microglia diagnose damaged circuits in an in vivo brain. Now a Japanese group has successfully taken a live image how microglia survey synapses in the brains of mice by using two-photon microscopic technology.

Microglia, immune cells in the brain, are suggested to be involved in the repair of damaged brain, like a medical doctor. However, it is completely unknown how microglia diagnose damaged circuits in an in vivo brain.

Related Articles


Now, a Japanese group led by Professor Junichi Nabekura and Dr Hiroaki Wake of National Institute for Physiological Sciences, NIPS, Japan, has successfully taken a live image how microglia survey the synapses in the intact and ischemic brains of mice by using two-photon microscopic technology.

They report their finding in Journal of Neuroscience on April 1, 2009.

In their study, the researchers took an intense tune-up of their two-photon microscopy and achieved to visualize the fine structures of neurons and glia of mice in the range of 0 to 1 mm from the brain surface (world-leading deep imaging technology).

Surprisingly, even in the normal (intact brain), microglia actively reached out their processes selectively for neuronal synapses at an interval of one hour with a contact duration of 5 minutes. More frequently, microglia contacted on more active synapses. Once the brain received the damage such as ischemic infarction, microglial surveillance of synapses was much prolonged in duration, up to 2 hours. Frequently after the prolonged survey by microglia, damaged synapses were eliminated. This is the first report to show how microglia actively survey the synapses in vivo and determines the fate of synapses, remained or eliminated

"Dynamic change of microglial surveillance of neuronal circuits in damaged brain, observed here, could contribute to establish the therapeutic approach targeted to damaged circuits," said Professor Nabekura.


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Cite This Page:

National Institute for Physiological Sciences. "How Do Microglia Examine Damaged Synapses?." ScienceDaily. ScienceDaily, 9 April 2009. <www.sciencedaily.com/releases/2009/03/090331183510.htm>.
National Institute for Physiological Sciences. (2009, April 9). How Do Microglia Examine Damaged Synapses?. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2009/03/090331183510.htm
National Institute for Physiological Sciences. "How Do Microglia Examine Damaged Synapses?." ScienceDaily. www.sciencedaily.com/releases/2009/03/090331183510.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Common Pain Reliever Might Dull Your Emotions

Common Pain Reliever Might Dull Your Emotions

Newsy (Apr. 16, 2015) Each week, millions of Americans take acetaminophen to dull minor aches and pains. Now researchers say it might blunt life&apos;s highs and lows, too. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins