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Hormone Prolactin Reduces Fat Metabolism

Date:
April 5, 2009
Source:
University of Gothenburg
Summary:
The hormone prolactin is necessary for the production of breast milk, but it also affects adipose (fatty) tissue and the body's metabolism. Raised prolactin levels in a woman who is not pregnant or breast feeding reduces lipid (fat) metabolism.

The hormone prolactin is necessary for the production of breast milk, but it also affects adipose (fatty) tissue and the body’s metabolism. This has been shown by a thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden. Raised prolactin levels in a woman who is not pregnant or breast feeding reduces lipid (fat) metabolism.

Over 30 000 Swedish men and women may have raised levels of prolactin. Women who are pregnant or breast feeding have naturally raised levels of prolactin, but stress, some medicines and benign brain tumours can also lead to raised levels of the hormone. In many cases doctors don’t know what causes the rise in hormone levels. In women, an abnormally high level can cause menstrual disturbances and infertility, and may also result in insulin resistance.

“In recent years scientists have also recognised the role of prolactin in the development of obesity, but little research has been done into the precise mechanism by which prolactin regulates metabolism,” says Louise Nilsson.

In her thesis Louise Nilsson shows that there are receptors for the breast feeding hormone in human fatty tissue.

“We have demonstrated that prolactin reduces the ability of fatty tissue to store sugar and fat, which then could accumulate in the blood and certain tissues instead. This in turn increases the risk of cardiovascular disease.”

Prolactin also affects the body’s ability to metabolise fat. An ongoing study suggests that the hormone impairs the body’s ability to maintain a balanced metabolism.

“When fatty tissue receives signals from prolactin, it reacts by reducing the production of another hormone called adiponectin, which is important for the metabolism of a variety of nutrients,” explains Louise Nilsson.


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The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "Hormone Prolactin Reduces Fat Metabolism." ScienceDaily. ScienceDaily, 5 April 2009. <www.sciencedaily.com/releases/2009/04/090402092859.htm>.
University of Gothenburg. (2009, April 5). Hormone Prolactin Reduces Fat Metabolism. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/04/090402092859.htm
University of Gothenburg. "Hormone Prolactin Reduces Fat Metabolism." ScienceDaily. www.sciencedaily.com/releases/2009/04/090402092859.htm (accessed October 20, 2014).

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