Featured Research

from universities, journals, and other organizations

Use Of Pancreatic Islets Show Promise In Diabetes Research, Treatments

Date:
April 15, 2009
Source:
JAMA and Archives Journals
Summary:
The use of pancreatic islets (hormone-producing cells) is increasing in diabetes research and may play an important role in future treatments, according to a new article.

The use of pancreatic islets (hormone-producing cells) is increasing in diabetes research and may play an important role in future treatments, according to an article in the April 15 issue of JAMA, a theme issue on diabetes.

John S. Kaddis, B.S., of the City of Hope National Medical Center, Duarte, Calif., presented the findings of the article at a JAMA media briefing at the National Press Club in Washington, D.C.

"The primary objective of islet-based research is to cure diabetes. Perhaps the most prominent clinical application of this research is currently in the form of cell replacement therapy. With the exception of 1 report in a type 2 diabetic cohort, islet transplantation has been used exclusively for a subset of individuals with type 1 diabetes mellitus and was shown, at least temporarily, to improve glucose control and, in a few cases, to lead to insulin independence," writes Mr. Kaddis and colleagues.

With this procedure, pancreatic islets are transplanted from a donated pancreas to a person with diabetes as a means of restoring beta-cell function. The destruction of beta cells in the pancreas is the cause of type 1 diabetes.

"Although islet transplantation has been shown to offer both protection against long-term complications of the disease and significant improvement in quality of life, several obstacles remain, such as limited engraftment [acceptance of the islets within the recipient], chronic immunosuppression, and inconsistent supply of human islets. These issues must be addressed if the procedure is to be used as a standard of care for qualified individuals," they write.

According to the authors, investigators seeking to understand the biology of human islets have approached the problem in a variety of ways. "Some have used surrogate beta cells and cell lines while others have focused on pancreas-derived isolated islets from human or nonhuman sources. Islets and islet-like cells have been used experimentally and clinically to increase beta-cell mass."

The demand for pancreatic islets for research and treatment has been increasing, with the production of human islets contingent on the availability of pancreata (plural for pancreas).

One of the barriers to islet production is the cost of acquiring organs, with data from the Islet Cell Resource (ICR) consortium showing that for 665 pancreata acquired from 2001 to 2008, standard acquisition charges ranged from a low of $600 to a high of $39,800.

To help address the supply and demand issues faced by islet laboratories and clinical and laboratory scientists, islet sharing networks have been established. "These distribution networks have had a global influence on diabetes research but face economic obstacles in preserving the availability of human islets in a growing research community."

Data indicate that 297.6 million islets were produced by 14 ICR laboratories between September 2001 and August 2008, with 67 percent used for basic science research and 31 percent for clinical purposes.

"The importance of human pancreatic islets, clinically or for basic science research, is substantiated by the number and quality of studies being performed that rely on these preparations. Data available through the ICR as of August 2008 indicate that a total of 151 national and international scientists received human islets for use in both intramural research performed by the consortium as well as 182 clinical and basic science projects submitted to the consortium for support," they write.

"Human pancreatic islets will be critical for restoration of beta-cell function in patients with diabetes. Even given adequate funding levels, the ongoing challenges to supplying human islets must be addressed for the successful exploration of therapeutic options for this chronic and debilitating disease," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. John S. Kaddis, BS; Barbara J. Olack; Janice Sowinski, MS; James Cravens, MPH; Juan L. Contreras, MD; Joyce C. Niland, PhD. Human Pancreatic Islets and Diabetes Research. JAMA, 2009;301(15):1580-1587 [link]

Cite This Page:

JAMA and Archives Journals. "Use Of Pancreatic Islets Show Promise In Diabetes Research, Treatments." ScienceDaily. ScienceDaily, 15 April 2009. <www.sciencedaily.com/releases/2009/04/090414102547.htm>.
JAMA and Archives Journals. (2009, April 15). Use Of Pancreatic Islets Show Promise In Diabetes Research, Treatments. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/04/090414102547.htm
JAMA and Archives Journals. "Use Of Pancreatic Islets Show Promise In Diabetes Research, Treatments." ScienceDaily. www.sciencedaily.com/releases/2009/04/090414102547.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins