Featured Research

from universities, journals, and other organizations

New Glaucoma Research Solves Anthropological And Medical Puzzle

Date:
April 15, 2009
Source:
Faculty of Medicine and Health of the University of Leeds
Summary:
Scientists studying a rare form of glaucoma have discovered why people in the disparate Roma communities are at greater risk of inheriting a condition leading to permanent blindness than other groups in the population.

Scientists studying a rare form of glaucoma have discovered why people in the disparate Roma communities are at greater risk of inheriting a condition leading to permanent blindness than other groups in the population.  

Related Articles


Primary congenital glaucoma (PCG) is a devastating condition affecting 1 in every 1000 Romany people. Researchers at the University of Leeds, looking to uncover the cause, found a single gene mutation repeatedly appearing in affected families.

An international collaboration led by Dr Manir Ali of the Leeds Institute of Molecular Medicine, first identified the ‘Jatt’ mutation in one of four Pakistani families. Further study amongst Roma populations in Europe showed that the same mutation accounted for nearly half of all cases of PCG in that community.

Dr Ali’s research also confirms the widely accepted view that the Roma originated from the Jatt clan of Northern India and Pakistan and not from Eastern Europe as previously believed.

Dr Ali said: “Glaucoma is the leading cause of preventable blindness worldwide and we are now looking at this same gene to see if changes in it are also found in patients with the more common form of glaucoma, primary open angle glaucoma (POAG) or chronic glaucoma, which affects so many older people.

“It is hoped that our research, which looked at a relatively rare form of the disease, can help medical professionals address the health needs and find appropriate treatments for a particularly vulnerable at-risk group,” he added.

Recognised as Europe’s largest ethnic minority, the Romany and Gypsy communities continue to suffer discrimination. An estimated 84% across Europe live below the recognised poverty line.

A recent Mori poll revealed that a third of UK residents admitted to being prejudiced against these groups. The British Medical Association says the Gypsy communities have the lowest life expectancy and the highest rate of child mortality in the UK.

One reason may be the difficulty these groups have in registering with a GP, which effectively excludes them from the health care system, routine screening and early diagnosis of disease.

Although the common form, chronic glaucoma, is difficult to detect in the early stages, early diagnosis offers real opportunities to treat this condition.  However, if left unchecked it leads to loss of vision and in some cases permanent blindness.

This means that regular eye examinations are essential, especially in high-risk groups, such as the elderly and those with a family history of the condition.


Story Source:

The above story is based on materials provided by Faculty of Medicine and Health of the University of Leeds. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ali et al. Null Mutations in LTBP2 Cause Primary Congenital Glaucoma. The American Journal of Human Genetics, 2009; DOI: 10.1016/j.ajhg.2009.03.017

Cite This Page:

Faculty of Medicine and Health of the University of Leeds. "New Glaucoma Research Solves Anthropological And Medical Puzzle." ScienceDaily. ScienceDaily, 15 April 2009. <www.sciencedaily.com/releases/2009/04/090415074850.htm>.
Faculty of Medicine and Health of the University of Leeds. (2009, April 15). New Glaucoma Research Solves Anthropological And Medical Puzzle. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/04/090415074850.htm
Faculty of Medicine and Health of the University of Leeds. "New Glaucoma Research Solves Anthropological And Medical Puzzle." ScienceDaily. www.sciencedaily.com/releases/2009/04/090415074850.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins