Featured Research

from universities, journals, and other organizations

Immune Cell Type Controls Onset And Course Of Severe Malaria

Date:
May 1, 2009
Source:
Public Library of Science
Summary:
Scientists have determined that a subset of immune cells may cause malaria patients to contract the severe form of the disease, suffering worse symptoms. The researchers found that patients with the severe form of malaria have a specific type of cell in their body that people with uncomplicated disease do not.

Scientists have determined that a subset of immune cells may cause malaria patients to contract the severe form of the disease, suffering worse symptoms.

Led by Monash University immunologist Professor Magdalena Plebanski, the international team found that patients with the severe form of malaria have a specific type of cell in their body that people with uncomplicated disease do not. This type of cell, described in an article published April 24 in the open access journal PLoS Pathogens, turns off the immune system and can allow the parasite to grow uncontrollably.

The research team included scientists from Monash University's Department of Immunology; Menzies School of Health Research in Darwin; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia as well as researchers from NIHRD-MSHR Collaborative Research Program and District Health Authority, Timika, Papua, Indonesia; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK and Queensland Institute of Medical Research, Brisbane, Australia.

Professor Plebanski and her team investigated the relationship between regulatory T (Treg) cells, parasite burden, and disease severity in adult malaria patients with either uncomplicated or severe malaria. When comparing Treg cell characteristics, the team was able to identify elevated levels of a new highly suppressive subset of Treg cells in those patients with severe malaria.

"The regulatory (Treg) cell subset associated with severe disease in humans expresses a unique combination of surface markers, including TNFRII . Regulatory T (Treg) cells are a small specialized subset of immune cells that suppress the activation and expansion of effector immune cells, which partake in parasite elimination," Professor Plebanski said.

"Our results indicate that severe malaria is accompanied by the induction of highly suppressive Treg cells that can promote parasite growth and caution against the induction of these Treg cells when developing effective malaria vaccines."

It is estimated that 500 million people live in areas where there is a risk of getting malaria. The severe form of the disease causes death in 1-3 million people each year. Professor Plebanski said until now it had been largely unknown what bodily factors enable some patients to fight and survive the disease, while other patients contract the severe form of the disease and sometimes die.

"Targeting this cell type may lead to new drugs and immunotherapeutics against malaria. Further studies are needed to determine if this new cell may also be promoting severe forms of other inflammatory diseases," Professor Plebanski said.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minigo G, Woodberry T, Piera KA, Salwati E, Tjitra E, et al. Parasite-Dependent Expansion of TNF Receptor II%u2013Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria. PLoS Pathog, 5(4): e1000402 DOI: 10.1371/journal.ppat.1000402

Cite This Page:

Public Library of Science. "Immune Cell Type Controls Onset And Course Of Severe Malaria." ScienceDaily. ScienceDaily, 1 May 2009. <www.sciencedaily.com/releases/2009/04/090424073740.htm>.
Public Library of Science. (2009, May 1). Immune Cell Type Controls Onset And Course Of Severe Malaria. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2009/04/090424073740.htm
Public Library of Science. "Immune Cell Type Controls Onset And Course Of Severe Malaria." ScienceDaily. www.sciencedaily.com/releases/2009/04/090424073740.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins