Featured Research

from universities, journals, and other organizations

Immune Cell Type Controls Onset And Course Of Severe Malaria

Date:
May 1, 2009
Source:
Public Library of Science
Summary:
Scientists have determined that a subset of immune cells may cause malaria patients to contract the severe form of the disease, suffering worse symptoms. The researchers found that patients with the severe form of malaria have a specific type of cell in their body that people with uncomplicated disease do not.

Scientists have determined that a subset of immune cells may cause malaria patients to contract the severe form of the disease, suffering worse symptoms.

Led by Monash University immunologist Professor Magdalena Plebanski, the international team found that patients with the severe form of malaria have a specific type of cell in their body that people with uncomplicated disease do not. This type of cell, described in an article published April 24 in the open access journal PLoS Pathogens, turns off the immune system and can allow the parasite to grow uncontrollably.

The research team included scientists from Monash University's Department of Immunology; Menzies School of Health Research in Darwin; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia as well as researchers from NIHRD-MSHR Collaborative Research Program and District Health Authority, Timika, Papua, Indonesia; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK and Queensland Institute of Medical Research, Brisbane, Australia.

Professor Plebanski and her team investigated the relationship between regulatory T (Treg) cells, parasite burden, and disease severity in adult malaria patients with either uncomplicated or severe malaria. When comparing Treg cell characteristics, the team was able to identify elevated levels of a new highly suppressive subset of Treg cells in those patients with severe malaria.

"The regulatory (Treg) cell subset associated with severe disease in humans expresses a unique combination of surface markers, including TNFRII . Regulatory T (Treg) cells are a small specialized subset of immune cells that suppress the activation and expansion of effector immune cells, which partake in parasite elimination," Professor Plebanski said.

"Our results indicate that severe malaria is accompanied by the induction of highly suppressive Treg cells that can promote parasite growth and caution against the induction of these Treg cells when developing effective malaria vaccines."

It is estimated that 500 million people live in areas where there is a risk of getting malaria. The severe form of the disease causes death in 1-3 million people each year. Professor Plebanski said until now it had been largely unknown what bodily factors enable some patients to fight and survive the disease, while other patients contract the severe form of the disease and sometimes die.

"Targeting this cell type may lead to new drugs and immunotherapeutics against malaria. Further studies are needed to determine if this new cell may also be promoting severe forms of other inflammatory diseases," Professor Plebanski said.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minigo G, Woodberry T, Piera KA, Salwati E, Tjitra E, et al. Parasite-Dependent Expansion of TNF Receptor II%u2013Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria. PLoS Pathog, 5(4): e1000402 DOI: 10.1371/journal.ppat.1000402

Cite This Page:

Public Library of Science. "Immune Cell Type Controls Onset And Course Of Severe Malaria." ScienceDaily. ScienceDaily, 1 May 2009. <www.sciencedaily.com/releases/2009/04/090424073740.htm>.
Public Library of Science. (2009, May 1). Immune Cell Type Controls Onset And Course Of Severe Malaria. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/04/090424073740.htm
Public Library of Science. "Immune Cell Type Controls Onset And Course Of Severe Malaria." ScienceDaily. www.sciencedaily.com/releases/2009/04/090424073740.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins