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Notch1 Contributes To Scar Tissue In The Lungs

Date:
May 5, 2009
Source:
American Journal of Pathology
Summary:
Researchers have identified Notch1 as a mediator of lung fibrosis. Scar tissue, or fibrosis, can accumulate in the lungs, restricting the flow of oxygen and leading to end-stage lung disease, respiratory failure, and eventually death.

A group led by Dr. Sem Phan at the University of Michigan, Ann Arbor identified Notch1 as a mediator of lung fibrosis.

They present their data in the May 2009 issue of The American Journal of Pathology.

Scar tissue, or fibrosis, can accumulate in the lungs, restricting the flow of oxygen and leading to end-stage lung disease, respiratory failure, and eventually death. An increase in the number of a special type of cells, myofibroblasts, strongly contributes to lung fibrosis.

FIZZ1, a protein found in the lungs, increases the number of myofibroblasts in the lungs. Liu et al hypothesized that Notch1, which regulates cell fate in numerous cell types, plays a role in FIZZ1-mediated myofibroblast differentiation. They found that Notch1 led to an increase of myofibroblasts in the lungs, and that mice that lacked Notch1 had decreased responses to FIZZ1 and lower levels of lung fibrosis.

Taken together, these data suggest that "Notch1 signaling in response to FIZZ1 may play a significant role in myofibroblast differentiation during lung fibrosis." Therefore, Notch1 may provide a novel target for treatment of scar tissue in the lungs.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Liu T, Hu B, Choi YY, Chung MJ, Ullenbruch M, Yu H, Lowe JB, Phan SH. Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation. American Journal Of Pathology, 2009; 174 (5): 1745 DOI: 10.2353/ajpath.2009.080618

Cite This Page:

American Journal of Pathology. "Notch1 Contributes To Scar Tissue In The Lungs." ScienceDaily. ScienceDaily, 5 May 2009. <www.sciencedaily.com/releases/2009/04/090426082452.htm>.
American Journal of Pathology. (2009, May 5). Notch1 Contributes To Scar Tissue In The Lungs. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/04/090426082452.htm
American Journal of Pathology. "Notch1 Contributes To Scar Tissue In The Lungs." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082452.htm (accessed October 20, 2014).

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