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TIP30 Inhibits Lung Cancer Metastasis, Study Suggests

Date:
May 1, 2009
Source:
American Journal of Pathology
Summary:
Researchers in China suggest that TIP30 prevents metastatic progression of lung cancer. TIP30 is a putative tumor suppressor with decreased expression in numerous cancers including melanoma, breast cancer, and colon cancer.
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Researchers in Shanghai, China suggest that TIP30 prevents metastatic progression of lung cancer.

They report these findings in the May 2009 issue of The American Journal of Pathology.

TIP30 is a putative tumor suppressor with decreased expression in numerous cancers including melanoma, breast cancer, and colon cancer. Lung cancer is the most common cancer worldwide, both in terms of incidence and of mortality.

To determine if TIP30 plays a role in lung cancer progression and metastasis, Tong et al examined TIP30 expression in paired cancerous and non-cancerous lung tissue. TIP30 expression was decreased in a third of non-small cell lung cancers compared with normal controls, and reduced TIP30 expression correlated with lymph node metastasis. In addition, inhibition of TIP30 expression promoted lung cancer metastasis and angiogenesis in mice,

Tong et al conclude that "TIP30 may function as a tumor suppressor gene and play important roles in suppressing the progression and metastasis of lung cancer." These findings highlight TIP30 as a potential new therapeutic for metastatic lung cancer.


Story Source:

The above post is reprinted from materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tong X, Li K, Luo Z, Lu B, Liu X, Wang T, Pang M, Liang B, Tan M, Wu M, Zhao J, Guo Y. Decreased TIP30 Expression Promotes Tumor Metastasis in Lung Cancer. American Journal Of Pathology, 2009; 174 (5): 1931 DOI: 10.2353/ajpath.2009.080846

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American Journal of Pathology. "TIP30 Inhibits Lung Cancer Metastasis, Study Suggests." ScienceDaily. ScienceDaily, 1 May 2009. <www.sciencedaily.com/releases/2009/04/090426082639.htm>.
American Journal of Pathology. (2009, May 1). TIP30 Inhibits Lung Cancer Metastasis, Study Suggests. ScienceDaily. Retrieved September 3, 2015 from www.sciencedaily.com/releases/2009/04/090426082639.htm
American Journal of Pathology. "TIP30 Inhibits Lung Cancer Metastasis, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082639.htm (accessed September 3, 2015).

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