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SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease

Date:
May 4, 2009
Source:
American Journal of Pathology
Summary:
Researchers have found that SPARC, a counter-adhesive protein, may contribute to kidney disease. Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins.

Amy Sussman and colleagues at the University of Washington, Seattle have found that SPARC may contribute to kidney disease.

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These findings are presented in the May 2009 issue of The American Journal of Pathology.

Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins. SPARC, a counter-adhesive protein, is upregulated in podocytes upon injury.

To define the role of SPARC in kidney disease, Sussman et al examined immune-mediated kidney disease in mice deficient in SPARC as well as in normal mice. They found that hardening of the kidney was reduced in SPARC-null mice compared with normal controls, in part due to maintenance of podocytes. In addition, SPARC-deficient podocytes were more resistant to stress-induced detachment.

Sussman et al "have established a causal role for SPARC in the progression of glomerular disease following immune-mediated injury of the podocyte. [These] findings support a causal role for induction of the matricellular protein SPARC in mediating podocyte loss, thereby accelerating [kidney] injury."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC Accelerates Disease Progression in Experimental Crescentic Glomerulonephritis. American Journal Of Pathology, 2009; 174 (5): 1827 DOI: 10.2353/ajpath.2009.080464

Cite This Page:

American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. ScienceDaily, 4 May 2009. <www.sciencedaily.com/releases/2009/04/090426082726.htm>.
American Journal of Pathology. (2009, May 4). SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/04/090426082726.htm
American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082726.htm (accessed October 25, 2014).

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