Featured Research

from universities, journals, and other organizations

SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease

Date:
May 4, 2009
Source:
American Journal of Pathology
Summary:
Researchers have found that SPARC, a counter-adhesive protein, may contribute to kidney disease. Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins.

Amy Sussman and colleagues at the University of Washington, Seattle have found that SPARC may contribute to kidney disease.

These findings are presented in the May 2009 issue of The American Journal of Pathology.

Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins. SPARC, a counter-adhesive protein, is upregulated in podocytes upon injury.

To define the role of SPARC in kidney disease, Sussman et al examined immune-mediated kidney disease in mice deficient in SPARC as well as in normal mice. They found that hardening of the kidney was reduced in SPARC-null mice compared with normal controls, in part due to maintenance of podocytes. In addition, SPARC-deficient podocytes were more resistant to stress-induced detachment.

Sussman et al "have established a causal role for SPARC in the progression of glomerular disease following immune-mediated injury of the podocyte. [These] findings support a causal role for induction of the matricellular protein SPARC in mediating podocyte loss, thereby accelerating [kidney] injury."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC Accelerates Disease Progression in Experimental Crescentic Glomerulonephritis. American Journal Of Pathology, 2009; 174 (5): 1827 DOI: 10.2353/ajpath.2009.080464

Cite This Page:

American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. ScienceDaily, 4 May 2009. <www.sciencedaily.com/releases/2009/04/090426082726.htm>.
American Journal of Pathology. (2009, May 4). SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/04/090426082726.htm
American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082726.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins