Featured Research

from universities, journals, and other organizations

SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease

Date:
May 4, 2009
Source:
American Journal of Pathology
Summary:
Researchers have found that SPARC, a counter-adhesive protein, may contribute to kidney disease. Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins.

Amy Sussman and colleagues at the University of Washington, Seattle have found that SPARC may contribute to kidney disease.

Related Articles


These findings are presented in the May 2009 issue of The American Journal of Pathology.

Chronic kidney disease is associated with significant injury and loss of podocytes, which are cells crucial for filtering the blood of toxins. SPARC, a counter-adhesive protein, is upregulated in podocytes upon injury.

To define the role of SPARC in kidney disease, Sussman et al examined immune-mediated kidney disease in mice deficient in SPARC as well as in normal mice. They found that hardening of the kidney was reduced in SPARC-null mice compared with normal controls, in part due to maintenance of podocytes. In addition, SPARC-deficient podocytes were more resistant to stress-induced detachment.

Sussman et al "have established a causal role for SPARC in the progression of glomerular disease following immune-mediated injury of the podocyte. [These] findings support a causal role for induction of the matricellular protein SPARC in mediating podocyte loss, thereby accelerating [kidney] injury."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC Accelerates Disease Progression in Experimental Crescentic Glomerulonephritis. American Journal Of Pathology, 2009; 174 (5): 1827 DOI: 10.2353/ajpath.2009.080464

Cite This Page:

American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. ScienceDaily, 4 May 2009. <www.sciencedaily.com/releases/2009/04/090426082726.htm>.
American Journal of Pathology. (2009, May 4). SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/04/090426082726.htm
American Journal of Pathology. "SPARC (Secreted Protein Acidic And Rich In Cysteine) In Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2009/04/090426082726.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins