Featured Research

from universities, journals, and other organizations

Elevated Level Of Certain Protein In Urine Linked To Increased Risk For Blood Clots

Date:
May 12, 2009
Source:
JAMA and Archives Journals
Summary:
Preliminary research suggests that higher than normal levels of the protein albumin in urine is associated with an increased risk for blood clots in the deep veins of the legs or lungs (venous thromboembolism; VTE).

Preliminary research suggests that higher than normal levels of the protein albumin in urine is associated with an increased risk for blood clots in the deep veins of the legs or lungs (venous thromboembolism; VTE).

Related Articles


The overall incidence of VTE in developed countries is about 0.15 percent per year, varying from less than 0.005 percent in individuals younger than 15 years to as high as 0.5 percent at 80 years of age. Known risk factors for VTE include stasis (a slowing of the normal flow) of the blood and changes in the composition of the blood. However, in as many as 50 percent of VTE cases, none of the known risk factors are present, according to background information in the article.

Microalbuminuria (albumin in urine; 30-300 mg per 24-hour urine collection) is associated with changes in the levels of several coagulation proteins. The effect of coagulation disorders is more evident in the development of VTE than of arterial thromboembolism (formation of a blood clot in the arterial system). "Hence, in theory, a link between microalbuminuria and VTE is likely; however, research addressing this issue has yet to be conducted," the authors write.

Bakhtawar K. Mahmoodi, B.Sc., of the University Medical Centre Groningen, the Netherlands, and colleagues conducted a study to assess whether microalbuminuria is associated with VTE. The ongoing, community-based study, started in 1997, includes all inhabitants of Groningen, the Netherlands, (age 28 through 75 years [n = 85,421]) who were sent a postal questionnaire and a vial to collect a urine sample for measurement of urinary albumin concentration. Of those who responded (40,856), a group (8,592) including more participants with higher levels of urinary albumin concentration completed screening at an outpatient clinic. Screening data were collected on urinary albumin excretion (UAE) and risk factors for cardiovascular and kidney disease.

Of 8,574 evaluable participants (average age, 49 years; 50 percent men), 129 developed at least 1 VTE during an average observation period of 8.6 years, corresponding to an annual incidence of 0.14 percent, ranging from 0.12 percent in participants with UAE of less than 15 mg/24 h to 0.56 percent in participants with UAE of greater than 300 mg/24 h. These annual incidences were 0.40 percent in microalbuminuric vs. 0.12 percent in normoalbuminuric participants (UAE less than 30 mg/24 hour urine collection).

During 8 years of follow-up, 3 percent of microalbuminuric participants and 1 percent of normoalbuminuric participants developed VTE. The most commonly encountered first VTE was deep vein thrombosis (57 percent; a blood clot in a deep vein in the thigh or leg), followed by pulmonary embolism (34 percent; a blood clot in a blood vessel in the lungs), and combined deep vein thrombosis and pulmonary embolism (9 percent).

"The fact that microalbuminuria has a high prevalence in the general population (7.2 percent) suggests that on the population level, microalbuminuria may be an important risk factor for VTE. Moreover, in contrast to most of the established VTE risk factors, microalbuminuria could be treated by nonanticoagulant medication. Future studies are needed to evaluate the effect of these drugs on the risk of VTE," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bakhtawar K. Mahmoodi; Ron T. Gansevoort; Nic J. G. M. Veeger; Abigail G. Matthews; Gerjan Navis; Hans L. Hillege; Jan van der Meer; for the Prevention of Renal and Vascular End-stage Disease (PREVEND) Study Group. Microalbuminuria and Risk of Venous Thromboembolism. JAMA, 2009;301(17):1790-1797 [link]

Cite This Page:

JAMA and Archives Journals. "Elevated Level Of Certain Protein In Urine Linked To Increased Risk For Blood Clots." ScienceDaily. ScienceDaily, 12 May 2009. <www.sciencedaily.com/releases/2009/05/090505162442.htm>.
JAMA and Archives Journals. (2009, May 12). Elevated Level Of Certain Protein In Urine Linked To Increased Risk For Blood Clots. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2009/05/090505162442.htm
JAMA and Archives Journals. "Elevated Level Of Certain Protein In Urine Linked To Increased Risk For Blood Clots." ScienceDaily. www.sciencedaily.com/releases/2009/05/090505162442.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins