Featured Research

from universities, journals, and other organizations

MiR-196a Promotes The Metastases Of Tumors

Date:
May 13, 2009
Source:
World Journal of Gastroenterology
Summary:
MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination.

MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination. miR-196a increased the chemosensitivity towards platin derivatives such as cisplatin and oxaliplatin and might be a useful biomarker.

Analysing the microRNA expression pattern in pancreatic cancer by microRNA chip analyses, Carlo Croce found that 75% of tumours expressed miR-196a at a high level, predicting poor patient survival. Yekta and colleagues first described a miR-196a-directed cleavage of specific homebox genes (HoxB8, HoxC8, HoxD8 and HoxA7) in mouse embryos and mammalian cells. As a tumour-suppressive effect of HoxC8 has been previously discussed in humans, it has been hypothesized that miR-196a might promote tumour progression.

Carl Schimanski and colleagues report that miR-196a supports tumour cell detachment and tumour cell dissemination in vitro via activation of the AKT pathway. In order to confirm these experiments, they performed animal studies with immune suppressed mice which received a tail vein injection of human tumour cells. Pretreatment of tumour cells with miR-196a lead to significantly more lung metastases in these animals.

Therefore, the authors conclude that miR-196a does support the development of metastases by exerting a pro-oncogenic function. Noteworthy, several other microRNA have been described that exert pro-oncogenic funtions, such as miR-17-92 which is significantly increased in small-cell lung cancer and decreases survival by inhibition of tumour-suppressor genes PTEN and RB2. The exact mode of function of miR-196a still needs to be analysed.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Schimanski et al. High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World Journal of Gastroenterology, 2009; 15 (17): 2089 DOI: 10.3748/wjg.15.2089

Cite This Page:

World Journal of Gastroenterology. "MiR-196a Promotes The Metastases Of Tumors." ScienceDaily. ScienceDaily, 13 May 2009. <www.sciencedaily.com/releases/2009/05/090513091343.htm>.
World Journal of Gastroenterology. (2009, May 13). MiR-196a Promotes The Metastases Of Tumors. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2009/05/090513091343.htm
World Journal of Gastroenterology. "MiR-196a Promotes The Metastases Of Tumors." ScienceDaily. www.sciencedaily.com/releases/2009/05/090513091343.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins