Featured Research

from universities, journals, and other organizations

Important Clue Found To Help Identify Common Cause Of Kidney Failure In Children

Date:
May 21, 2009
Source:
American Society of Nephrology
Summary:
Researchers are zeroing in on the genetic abnormalities predisposing to vesicoureteric reflux, one of the most common causes of urinary tract infections and kidney failure in children.

Researchers are zeroing in on the genetic abnormalities predisposing to vesicoureteric reflux (VUR), one of the most common causes of urinary tract infections and kidney failure in children, reports a new study. "In this study, we accomplished a very critical step towards the identification of the VUR gene," says Ali G. Gharavi, MD (Columbia University, New York).

Led by Patricia L. Weng, MD (Mount Sinai School of Medicine), and Simone Sann-Cherchi, MD (Columbia University), the researchers, including Gharavi, performed genetic studies in 16 large families affected by VUR. "In VUR, a faulty valve in the bladder allows urine to flow back, or 'reflux,' up to the kidneys," Gharavi explains. If VUR persists, it can lead to repeated urinary tract infections and kidney failure. It affects about one percent of children and runs in families.

A method called linkage analysis was used to pinpoint the location of the abnormal genes associated with VUR. "We narrowed down the location of the VUR susceptibility gene to a region on chromosome 12 that is less than one percent of the entire genome," says Gharavi.

In contrast to previous studies, the VUR susceptibility gene appeared to be inherited in autosomal recessive fashion—affected children inherit one copy of the faulty gene from each parent. According to Gharavi, "This means that there are many different inherited forms of VUR, some with dominant and some with recessive inheritance."

The next step will be conducting studies to identify the exact gene predisposing to VUR. "We plan to study more families and other patients with VUR so that we can better understand how the kidney and urinary tract develop and then create better diagnostic tests and treatments," Gharavi adds.

Although the study does not identify the gene causing VUR, it represents the initial, critical step towards achieving that goal. The study was limited to a specific group of Caucasian patients; more research will be needed to determine whether the results apply to other populations and ethnicities.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Weng et al. A Recessive Gene for Primary Vesicoureteral Reflux Maps to Chromosome 12p11-q13. Journal of the American Society of Nephrology, May 14, 2009; DOI: 10.1681/ASN.2008111199

Cite This Page:

American Society of Nephrology. "Important Clue Found To Help Identify Common Cause Of Kidney Failure In Children." ScienceDaily. ScienceDaily, 21 May 2009. <www.sciencedaily.com/releases/2009/05/090514170801.htm>.
American Society of Nephrology. (2009, May 21). Important Clue Found To Help Identify Common Cause Of Kidney Failure In Children. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/05/090514170801.htm
American Society of Nephrology. "Important Clue Found To Help Identify Common Cause Of Kidney Failure In Children." ScienceDaily. www.sciencedaily.com/releases/2009/05/090514170801.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins