Featured Research

from universities, journals, and other organizations

How Embryo Movement Stimulates Joint Formation

Date:
May 22, 2009
Source:
Cell Press
Summary:
A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research answers a longstanding question about the influence of muscle activity on developing joints and underscores the critical contribution of movement to regulation of a signaling pathway that is important during development and beyond.

A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research, published by Cell Press in the May issue of the journal Developmental Cell, answers a longstanding question about the influence of muscle activity on developing joints and underscores the critical contribution of movement to regulation of a signaling pathway that is important during development and beyond.

Related Articles


Joint development requires changes in gene expression that "commit" cells to becoming part of the developing joint and distinguish them from the surrounding cartilage tissue. Previous research has shown that the Wnt/β-catenin signaling pathway plays a key role in maintaining this joint cell fate and preventing joint cells from differentiating into cartilage.

It is also clear that muscle contraction is involved in proper formation of the skeleton. "We have known for over a century that embryonic movement is intimately involved in development of the joints. However, the precise mechanism by which active musculature regulates joint formation has remained elusive," explains senior study author Dr. Elazar Zelzer from the Department of Molecular Genetics at the Weizmann Institute of Science in Israel.

Dr. Zelzer and colleagues confirmed that the normal process of joint formation was disrupted in mouse models that lacked limb musculature or muscle contractility. They then noted that cells at the presumptive joint sites ceased to express classical joint markers and instead followed a pathway for developing cartilage. Local loss of β-catenin activity explained why the joints failed to form.

"Prior to the current study, the mechanisms that underlie the contribution of movement to the process of joint development were mostly missing," says Dr. Zelzer. "Our findings show that muscle contraction is necessary to maintain joint progenitor cell fate and explain how and why movement-induced mechanical stimuli play a key role during development."

Importantly, the current results also establish joint formation as a context in which to study mechanical regulation of the Wnt/β-catenin signaling more generally. The ability to respond to mechanical stimuli may also affect β-catenin-related tumorigenesis in disorders such as colon cancer.

The researchers include Joy Kahn, Weizmann Institute of Science, Rehovot, Israel; Yulia Shwartz, Weizmann Institute of Science, Rehovot, Israel; Einat Blitz, Weizmann Institute of Science, Rehovot, Israel; Sharon Krief, Weizmann Institute of Science, Rehovot, Israel; Amnon Sharir, Weizmann Institute of Science, Rehovot, Israel, Hebrew University of Jerusalem, Rehovot, Israel; Dario. A. Breitel, Weizmann Institute of Science, Rehovot, Israel; Revital Rattenbach, INSERM-UPMC-Paris VI, Faculte´ de Medecine Pitie-Salpetriere, Paris, France; Frederic Relaix, INSERM-UPMC-Paris VI, Faculte´ de Medecine Pitie-Salpetriere, Paris, France; Pascal Maire, INSERM U567, CNRS UMR8104 Universite´ Paris Descartes, Paris, France; Ryan B. Rountree, Stanford University School of Medicine, Stanford, CA; David M. Kingsley, Stanford University School of Medicine, Stanford, CA; and Elazar Zelzer, Weizmann Institute of Science, Rehovot, Israel.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Joy Kahn, Yulia Shwartz, Einat Blitz, Sharon Krief, Amnon Sharir, Dario. A. Breitel, Revital Rattenbach, Frederic Relaix, Pascal Maire, Ryan B. Rountree, David M. Kingsley, Elazar Zelzer. Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate. Developmental Cell, 2009; 16 (5): 734-743 DOI: 10.1016/j.devcel.2009.04.013

Cite This Page:

Cell Press. "How Embryo Movement Stimulates Joint Formation." ScienceDaily. ScienceDaily, 22 May 2009. <www.sciencedaily.com/releases/2009/05/090518120951.htm>.
Cell Press. (2009, May 22). How Embryo Movement Stimulates Joint Formation. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/05/090518120951.htm
Cell Press. "How Embryo Movement Stimulates Joint Formation." ScienceDaily. www.sciencedaily.com/releases/2009/05/090518120951.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins