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Childhood Cancer Survivors Have Persistent High Risk For Cancer Throughout Their Lives

Date:
May 31, 2009
Source:
Journal of the National Cancer Institute
Summary:
Childhood cancer survivors have a persistent and high risk for a second primary cancer throughout their lives, according to a new study.

Childhood cancer survivors have a persistent and high risk for a second primary cancer throughout their lives, according to a new study published in the Journal of the National Cancer Institute.

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Previous studies established that second primary cancer risk after treatment in childhood is higher than that in the general population, but follow-up was restricted to a few decades and the incidence in long-term survivors was rarely investigated. This study presents data for incidence of second cancers among childhood cancer patients in the Nordic countries over a full age range, from birth to age 79.

In the study, Jψrgen H. Olsen, M.D., of the Institute of Cancer Epidemiology, Danish Cancer Society, in Copenhagen, Denmark, and colleagues studied a cohort of 47,697 people who were diagnosed with cancer prior to the age of 20, from 1943 to 2005. Members of the cohort were followed for subsequent primary cancers listed in registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs).

The researchers found that the observed incidence rate of new primary cancers was higher than the expected rates, and the relative risk of second primary cancers was statistically significantly increased in all age groups. A total of 1,180 second primary cancers were observed in 1,088 persons, yielding a SIR of 3.3, with the brain as the most common site. They also found that the relative risk for second primary cancers in male survivors was statistically significantly higher than in female survivors.

"This study quantified long-term temporal patterns of increased risk of cancer at specific sites in survivors of childhood cancer," the authors write. "The results may be useful in the screening and care of these individuals."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Olsen et al. Lifelong Cancer Incidence in 47 697 Patients Treated for Childhood Cancer in the Nordic Countries. J Natl Cancer Inst, 2009, 101: 806-813

Cite This Page:

Journal of the National Cancer Institute. "Childhood Cancer Survivors Have Persistent High Risk For Cancer Throughout Their Lives." ScienceDaily. ScienceDaily, 31 May 2009. <www.sciencedaily.com/releases/2009/05/090526162840.htm>.
Journal of the National Cancer Institute. (2009, May 31). Childhood Cancer Survivors Have Persistent High Risk For Cancer Throughout Their Lives. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2009/05/090526162840.htm
Journal of the National Cancer Institute. "Childhood Cancer Survivors Have Persistent High Risk For Cancer Throughout Their Lives." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526162840.htm (accessed January 25, 2015).

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