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Developmental Experiences May Explain 'Unexplained' Medical Symptoms?

Date:
June 17, 2009
Source:
Journal of Psychotherapy and Psychosomatics
Summary:
A new theory on the role of developmental experiences has been described. Maternal perception of a threatening environment may be transmitted to the fetus when hormones cross the placenta and affect fetal physiology, effectively 'programming' the fetal stress response system and associated behaviors toward enhanced vigilance.

A new theory on the role of developmental experiences is presented in the current issue of Psychotherapy and Psycosomatics.

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Medically unexplained (or 'functional') symptoms (MUS) are physical symptoms that prompt the sufferer to seek healthcare but remain unexplained after an appropriate medical evaluation. Examples of MUS also occur in veterinary medicine. For example, domestic cats suffer a syndrome comparable to interstitial cystitis, a chronic pelvic pain syndrome of humans.

Review of current evidence suggests the hypothesis that developmental factors may play a role in some cases of MUS. Maternal perception of a threatening environment may be transmitted to the fetus when hormones cross the placenta and affect fetal physiology, effectively 'programming' the fetal stress response system and associated behaviors toward enhanced vigilance.

After birth, intense stress responses in the individual may result in similar vulnerability, which may be unmasked by subsequent stressors. Epigenetic modulation of gene expression (EMGEX) appears to play a central role in creation of this 'survival phenotype'. The recent development of techniques to identify the presence of EMGEX provides new tools to investigate these questions, and drugs and other interventions that may reverse EMGEX are also under active investigation.

Viewing medically unexplained (or 'functional') symptoms from the perspective of underlying developmental influences involving epigenetic modulation of gene expression that affect function of a variety of organs based on familial (genetic and environmental) predispositions rather than from the traditional viewpoint of isolated organ-originating diseases has at least two important implications: it provides a parsimonious explanation for findings heretofore difficult to reconcile, and it opens whole new areas of investigation into causes and treatments for this class of disorders.


Story Source:

The above story is based on materials provided by Journal of Psychotherapy and Psychosomatics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Buffington et al. Developmental Influences on Medically Unexplained Symptoms. Psychotherapy and Psychosomatics, 2009; 78 (3): 139 DOI: 10.1159/000206866

Cite This Page:

Journal of Psychotherapy and Psychosomatics. "Developmental Experiences May Explain 'Unexplained' Medical Symptoms?." ScienceDaily. ScienceDaily, 17 June 2009. <www.sciencedaily.com/releases/2009/06/090616080139.htm>.
Journal of Psychotherapy and Psychosomatics. (2009, June 17). Developmental Experiences May Explain 'Unexplained' Medical Symptoms?. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2009/06/090616080139.htm
Journal of Psychotherapy and Psychosomatics. "Developmental Experiences May Explain 'Unexplained' Medical Symptoms?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090616080139.htm (accessed March 3, 2015).

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