Featured Research

from universities, journals, and other organizations

Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier

Date:
June 19, 2009
Source:
University of Gothenburg
Summary:
It is possible to determine which patients run a high risk of developing Alzheimer's disease and the dementia associated with it, even in patients with minimal memory impairment.

It is possible to determine which patients run a high risk of developing Alzheimer’s disease and the dementia associated with it, even in patients with minimal memory impairment. This has been shown by recent research at the Sahlgrenska Academy.

Related Articles


The results have just been published in the medical journal Lancet Neurology.

"The earlier we can catch Alzheimer’s disease, the more we can do for the patient. The disease is one that progresses slowly, and the pharmaceuticals that are currently available are only able to alleviate the symptoms", says Kaj Blennow, professor at the Sahlgrenska Academy.

Several biomarkers have been identified in recent years. Biomarkers are proteins that can be detected in the cerebrospinal fluid and used to diagnose Alzheimer’s disease. It is now clear that the typical pattern of biomarkers known as the "CSF AD profile" can be seen in the cerebrospinal fluid of patients even with very mild memory deficiencies, before these can be detected by other tests.

"The patients who had the typical changes in biomarker profile of the cerebrospinal fluid had a risk of deterioration that was 27 times higher than the control group. We could also see that all patients with mild cognitive impairment who deteriorated and developed Alzheimer’s disease had these changes in the biomarker profile of their cerebrospinal fluid", says Kaj Blennow.

The scientists were also able to show a relationship between the profile of biomarkers and other typical signs of the disease, such as the presence of the gene APOE e4 and atrophy of the hippocampus, which is the part of the brain cortex that controls memory.

"Our discovery that an analysis of biomarkers in the cerebrospinal fluid can reveal Alzheimer’s disease at a very early stage will have major significance if the new type of pharmaceutical that can directly slow the progression of the disease proves to have a clinical effect. It is important in this case to start treatment before the changes in the brain have become too severe", says Kaj Blennow.

The research is part of a European research project known as DESCRIPA. Samples from 168 patients from seven countries are included in the study.

Alzheimer’s disease

Alzheimer’s disease is one of the most widespread diseases in Sweden, with more than 100,000 people being affected. The disease is caused by harmful changes to the nerve cells in the brain, and it principally affects memory. The disease often leads to early death. Alzheimer’s disease not only causes untold suffering for patients and their families, it also gives rise to enormous costs for society.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Piter Jelle Visser, Frans Verhey, Dirk L Knol, Philip Scheltens, Lars-Olof Wahlund, Yvonne Freund-Levi, Magda Tsolaki, Lennart Minthon, Εsa K Wallin, Harald Hampel, Katharina Bόrger, Tuula Pirttila, Hilkka Soininen, Marcel Olde Rikkert, Marcel Verbeek, Luiza Spiru, Kaj Blennow. Prevalence and prognostic value of CSF markers of Alzheimer%u2019s disease pathology in patients with subjective cognitive impairment and mild cognitive impairment in the DESCRIPA study: a prospective, case-control study. The Lancet Neurology, Volume 8, Issue 7, Pages 619 - 627

Cite This Page:

University of Gothenburg. "Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier." ScienceDaily. ScienceDaily, 19 June 2009. <www.sciencedaily.com/releases/2009/06/090618093240.htm>.
University of Gothenburg. (2009, June 19). Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2009/06/090618093240.htm
University of Gothenburg. "Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier." ScienceDaily. www.sciencedaily.com/releases/2009/06/090618093240.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) — President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) — Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) — The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins