Featured Research

from universities, journals, and other organizations

Early Infection And Protection Against Allergies?

Date:
June 24, 2009
Source:
The Swedish Research Council
Summary:
Allergies have become more common in the last few decades. It is still not fully clear why certain people develop allergies, but a strong risk factor is if the mother is allergic. Also, changes in life style are seen as playing a major role and several studies indicate that early exposure to bacteria and viruses may reduce the risk of allergies later in life.

When infected, the body has two types of immune defence to deploy – innate immunity and acquired immunity. In her dissertation, Shanie Saghafian Hedengren studies monocytes, a type of white blood corpuscles that are part of the innate immune system.

“Innate immunity plays a crucial role at the beginning of life as protection against bacteria and other microbes, since the acquired immune system is not fully developed at that stage. What’s more, acquired immunity and its memory are formed by ‘communication molecules’ that are initially transmitted by monocytes, among other sources. Imbalance in the monocyte function, as a result of less stimulation by microbes and viruses early in life, may therefore play an important role in the development of allergies,” maintains Shanie Saghafian Hedengren.

In this dissertation, a group of children is followed from birth to the age of five years. It shows the correlation between Epstein-Barr virus (EBV) contraction before the age of two and a lower risk of producing antibodies against allergens, so-called allergic sensitization. It is also of interest that EBV infection after the age of two was correlated with a greater risk of sensitization in five-year-olds.

EBV is a common herpesvirus that the majority of the world’s population carry throughout their lives. It is a highly successful virus that is normally spread via saliva and infects people early in life. Most people hardly notice when their children become infected.

“Contracting EBV later in life can lead to glandular fever, and apace with greater affluence, increased numbers of glandular fever cases have been reported. Perhaps from an evolutionary perspective it is more advantageous for both the virus and its host to meet earlier in life,” says Shanie Saghafian Hedengren.

The dissertation shows that the innate immunity in EBV-infected children also reacts in a mitigated way, which may explain why early infection normally produces no symptoms. These findings contradict the accepted view that what we might expect in this group with a lower risk for sensitization. Further, Shanie Saghafian Hedengren shows that newborn children have weaker monocyte responses to microbes up to the age of two if they have an allergic mother.

“Nevertheless, these high-risk children need adequate immune stimulation early in life in order to reduce the risk of allergies. In other words, lots of love for the youngest babies in the form of many and sloppy kisses,” concludes Shanie Saghafian Hedengren.

Dissertation title: Microbial and maternal influences on allergic sensitization during childhood: defining a role for monocytes.


Story Source:

The above story is based on materials provided by The Swedish Research Council. Note: Materials may be edited for content and length.


Cite This Page:

The Swedish Research Council. "Early Infection And Protection Against Allergies?." ScienceDaily. ScienceDaily, 24 June 2009. <www.sciencedaily.com/releases/2009/06/090623150129.htm>.
The Swedish Research Council. (2009, June 24). Early Infection And Protection Against Allergies?. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/06/090623150129.htm
The Swedish Research Council. "Early Infection And Protection Against Allergies?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623150129.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins