Featured Research

from universities, journals, and other organizations

Gastrin Plays Significant Role In Helicobacter-induced Stomach Cancer

Date:
June 28, 2009
Source:
Columbia University Medical Center
Summary:
Scientists have studied the role of Helicobacter infection in the development of stomach cancer, and found that the hormone gastrin, which stimulates secretion of gastric acid, plays a key role in the development of Helicobacter-induced stomach cancer, may have distinct effects on carcinogenesis in different parts of the stomach.

A group led by Columbia University Medical Center's Timothy Wang, M.D., has studied the role of Helicobacter infection in the development of stomach cancer and found that the hormone gastrin, which stimulates secretion of gastric acid, plays a key role in the development of Helicobacter-induced stomach cancer, and may have distinct effects on carcinogenesis in different parts of the stomach.

More than 50 percent of the world's population is infected with Helicobacter, which causes chronic inflammation of the stomach lining and is strongly linked to the development of gastric ulcers and stomach cancer. Stomach cancer is the second leading cause of cancer-related deaths worldwide.

Helicobacter infection results in increased expression of gastrin, although its role in cancer development has been unclear. High levels of gastrin lead to the development of stomach cancer, but absence of gastrin has been shown to increase the numbers of tumors in the gastric antrum, the lower section of the stomach that empties into the small intestine.

To reconcile this apparent incongruity, a group led by Dr. Wang studied Helicobacter infection and stomach cancer in animal models with either high expression of gastrin or no gastrin at all. They found that Helicobacter infection in mice with high levels of gastrin resulted in cancer of the gastric corpus (main body of the stomach), whereas infection in gastrin-deficient mice developed cancer in the gastric antrum.

Dr. Wang, with CUMC's Dr. Shigeo Takaishi, and their colleagues, argue that gastrin may serve as a "rheostat" for the stomach. Gastrin likely plays a central role in the safety network for the protection from mucosal damage caused by gastric acid secretion induced by gastrin itself, and thus either too much or too little gastrin could predispose a person to stomach cancer. Therefore, clinicians in the future may need to be more careful about prescribing acid-suppressive drugs for long-term use in patients infected with Helicobacter, Dr. Wang says.

In future studies, Dr. Wang and colleagues plan to study "host factors other than gastrin that are also important for Helicobacter-associated gastric carcinogenesis." These include specific cytokines and chemokines induced by Helicobacter infection and modulated by gastrin, that link inflammation and cancer. In addition, they plan to study the role of other non-Helicobacter bacteria that colonize the stomach when acid secretion is suppressed, since bacterial overgrowth likely contributes to gastric carcinogenesis.

The work was supported by grants from the National Institutes of Health, the Medical Research Council, the Welcome Trust and the Wolfson Foundation.


Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Takaishi S, Tu S, Dubeykovskaya ZA, Whary MT, Muthupalani S, Rickman BH, Rogers AB, Lertkowit N, Varro A, Fox JG, Wang TC. Gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice. Am J Pathol, 2009 175: 2775-2786

Cite This Page:

Columbia University Medical Center. "Gastrin Plays Significant Role In Helicobacter-induced Stomach Cancer." ScienceDaily. ScienceDaily, 28 June 2009. <www.sciencedaily.com/releases/2009/06/090624161624.htm>.
Columbia University Medical Center. (2009, June 28). Gastrin Plays Significant Role In Helicobacter-induced Stomach Cancer. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/06/090624161624.htm
Columbia University Medical Center. "Gastrin Plays Significant Role In Helicobacter-induced Stomach Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/06/090624161624.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins