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Gadolinium-based Contrast Agents Alone Don't Cause Patients To Develop Nephrogenic Systemic Fibrosis

Date:
June 30, 2009
Source:
American Roentgen Ray Society
Summary:
Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis in patients with kidney problems, according to a new study. NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures.

Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems, according to a study performed at the Mayo Clinic Florida, Jacksonville, FL.

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NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures.

The study examined the records of 61 patients. “Our patients had been given high doses—from two to ten times the usual MRI dose. These high doses were used because the patients were undergoing interventional procedures and the procedures were done before there were any reports linking gadolinium to NSF,” said Mellena D. Bridges, MD, lead author of the study. “Fortunately, one of these patients, a 58-year-old diabetic man with end-stage kidney disease and significant blood vessel blockages, developed NSF. Gadolinium seems to be necessary to trigger NSF, but it doesn’t seem to be enough to cause the disease, even at very high doses,” said Dr. Bridges.

This study appears in the June issue of the American Journal of Roentgenology.


Story Source:

The above story is based on materials provided by American Roentgen Ray Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bridges et al. High-Dose Gadodiamide for Catheter Angiography and CT in Patients With Varying Degrees of Renal Insufficiency: Prevalence of Subsequent Nephrogenic Systemic Fibrosis and Decline in Renal Function. American Journal of Roentgenology, 2009; 192 (6): 1538 DOI: 10.2214/AJR.07.3895

Cite This Page:

American Roentgen Ray Society. "Gadolinium-based Contrast Agents Alone Don't Cause Patients To Develop Nephrogenic Systemic Fibrosis." ScienceDaily. ScienceDaily, 30 June 2009. <www.sciencedaily.com/releases/2009/06/090630163111.htm>.
American Roentgen Ray Society. (2009, June 30). Gadolinium-based Contrast Agents Alone Don't Cause Patients To Develop Nephrogenic Systemic Fibrosis. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/06/090630163111.htm
American Roentgen Ray Society. "Gadolinium-based Contrast Agents Alone Don't Cause Patients To Develop Nephrogenic Systemic Fibrosis." ScienceDaily. www.sciencedaily.com/releases/2009/06/090630163111.htm (accessed October 31, 2014).

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