Featured Research

from universities, journals, and other organizations

Delirium In Hospitalized Adults: Situation Critical, No Relief Available

Date:
July 9, 2009
Source:
Indiana University
Summary:
In a systematic review of the scientific literature on delirium prevention and treatment, investigators found that despite the significant health and financial burdens of delirium for hospitalized adults, no effective way to prevent or treat the condition has been identified.

Every year as many as seven million adults in the United States experience delirium during hospitalization. In a systematic review of the scientific literature on delirium prevention and treatment, investigators from Indiana University School of Medicine, the Regenstrief Institute and Wishard Health Services found that despite the significant health and financial burdens of delirium for hospitalized adults, no effective way to prevent or treat the condition has been identified.

"Having delirium prolongs the length of a hospital stay, increases the risk of post-hospitalization transfer to a nursing home and doubles the risk of death. We need to identify a safe and effective drug to prevent and treat delirium. With our review we are challenging the scientific community to come up with new therapeutic options," said Malaz Boustani, M.D., senior author of the study which appears in the July 2009 issue of the Journal of General Internal Medicine. Dr. Boustani is a Regenstrief Institute investigator and associate professor of medicine at the IU School of Medicine.

Delirium, experienced by a significant number of older patients in surgical and critical care units and over half of older adults who are hospitalized for broken hips, is a state of confusion in which the individual has undergone a sudden alteration of mental status. Delirium is not dementia, but individuals with dementia are more susceptible to developing delirium during hospitalization than individuals without dementia.

The researchers found that only 13 randomized controlled studies on promising drugs for delirium were conducted from January 1966 to October 2008. These studies identified and evaluated 15 drugs including first and second generation antipsychotics, the drugs currently prescribed by most physicians for patients with delirium. The researchers found that neither older agents nor newer, more expensive medications were effective in preventing delirium. The study also found no difference between antipsychotics in treating delirium. To date, there are no U.S. Food and Drug Administration approved drugs to prevent or manage delirium according to Dr. Boustani.

"Research on delirium is at a point similar to where Alzheimer disease research was 30 years ago. The scientific and policy communities should encourage the FDA to provide guidance regarding the evaluation of potential new therapies for delirium. Hopefully this will promote rapid drug discovery and translation into delivery for patient care," said Dr. Boustani.

For vulnerable older adults only a slight insult, such as developing a urinary tract infection or taking an over-the-counter drug with anti-cholinergic effects (including many popular brands of sleeping pills), may lead to delirium. Less vulnerable individuals may require a more major insult, such as a stroke or heart attack, to trigger delirium, according to Dr. Boustani, who sees patients at the Healthy Aging Brain Center at the IU Center for Senior Health at Wishard.

"Our review found that drugs that affect the sleep-wake cycle, or that manage pain after surgery, may help prevent delirium," said Wishard Health Services pharmacist Noll Campbell, Pharm.D., first author of the study. "However, these treatment targets remain preliminary and require further study before they are accepted into widespread use."

The systematic evidence review was funded by the John A. Hartford Foundation, the Atlantic Philanthropies, the Starr Foundation, the National Institute on Aging and the American Federation of Aging Research.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Campbell et al. Pharmacological Management of Delirium in Hospitalized Adults -- A Systematic Evidence Review. Journal of General Internal Medicine, 2009; 24 (7): 848 DOI: 10.1007/s11606-009-0996-7

Cite This Page:

Indiana University. "Delirium In Hospitalized Adults: Situation Critical, No Relief Available." ScienceDaily. ScienceDaily, 9 July 2009. <www.sciencedaily.com/releases/2009/07/090706113652.htm>.
Indiana University. (2009, July 9). Delirium In Hospitalized Adults: Situation Critical, No Relief Available. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2009/07/090706113652.htm
Indiana University. "Delirium In Hospitalized Adults: Situation Critical, No Relief Available." ScienceDaily. www.sciencedaily.com/releases/2009/07/090706113652.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins