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Heavy, Daily Drinking Increases Risk Of High-Grade Prostate Cancer; Makes Preventive Drug Ineffective

Date:
July 14, 2009
Source:
Wiley - Blackwell
Summary:
Current research is inconclusive regarding the relationship between alcohol consumption and prostate cancer risk. Researchers examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with risks of total, low- and high-grade prostate cancer.

Current research is inconclusive regarding the relationship between alcohol consumption and prostate cancer risk. Researchers led by Zhihong Gong Ph.D. of the University of California San Francisco, examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with risks of total, low- and high-grade prostate cancer.

They used data from more than 10,000 men participating in the Prostate Cancer Prevention Trial (PCPT). They found participants who reported heavy alcohol consumption (≥50 g alcohol/day) and regular heavy drinking (≥4 drinks/day on ≥5 days per week) were twice as likely or more to be diagnosed with high-grade prostate cancer (RR: 2.01, and 2.17, respectively). Less heavy drinking was not associated with risk.

They also compared drinking patterns with treatment outcome among men enrolled on this placebo-controlled trial of the drug finasteride. They found finasteride's ability to lower prostate cancer risk was blocked in men drinking <50g alcohol per day.

They conclude heavy, daily drinking increases the risk of high-grade prostate cancer and that heavy drinking made finasteride ineffective for reducing prostate cancer risk.


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhihong Gong, Alan R. Kristal, Jeannette M. Schenk, Catherine M. Tangen, Phyllis J. Goodman, and Ian M. Thompson. Alcohol Consumption, Finasteride and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial. Cancer, Published Online: July 13, 2009; Print Issue Date: August 15, 2009 DOI: 10.1002/cncr.24423

Cite This Page:

Wiley - Blackwell. "Heavy, Daily Drinking Increases Risk Of High-Grade Prostate Cancer; Makes Preventive Drug Ineffective." ScienceDaily. ScienceDaily, 14 July 2009. <www.sciencedaily.com/releases/2009/07/090713085602.htm>.
Wiley - Blackwell. (2009, July 14). Heavy, Daily Drinking Increases Risk Of High-Grade Prostate Cancer; Makes Preventive Drug Ineffective. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/07/090713085602.htm
Wiley - Blackwell. "Heavy, Daily Drinking Increases Risk Of High-Grade Prostate Cancer; Makes Preventive Drug Ineffective." ScienceDaily. www.sciencedaily.com/releases/2009/07/090713085602.htm (accessed July 31, 2014).

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