Featured Research

from universities, journals, and other organizations

Network Of Altered Genes Appear To Play Role In Development Of Brain Tumors

Date:
July 21, 2009
Source:
JAMA and Archives Journals
Summary:
The interaction between a network of altered genes appears to play an important role in the development and progression of brain tumors, according to a new study.

The interaction between a network of altered genes appears to play an important role in the development and progression of brain tumors, according to a new study.

Malignant gliomas (brain tumors) are associated with disproportionately high illness and death and are among the most devastating of tumors. Particular genomic alterations are fundamental to both their formation and their malignant progression. "Chromosomal alterations presumably exert their tumor-promoting effect on glioma cells by modifying the expression or function of distinct genes, which map to those alterations, so as to deregulate growth factor signaling and survival pathways. For many chromosomal alterations, the biologically relevant target genes remain to be discovered," the authors write.

Oncogenic research on brain tumors has focused on the tumor-promoting or tumor-suppressive function of target genes within individual chromosomal alterations. However, these alterations do not exist in isolation, nor do single genes account for gliomagenesis. Rather, there may be mechanistic links to genes at other, coincident alterations, according to background information in the article.

Markus Bredel, M.D., Ph.D., of the Northwestern Brain Tumor Institute at Northwestern University Feinberg School of Medicine, Chicago, and colleagues examined the relationships of tumor-promoting genes in gliomas. The study included genomic profiles and clinical profiles of 501 patients with gliomas (45 tumors in an initial discovery set collected between 2001 and 2004 and 456 tumors in validation sets made public between 2006 and 2008) from multiple academic centers in the United States and The Cancer Genome Atlas Pilot Project (TCGA). The analysis included the identification of genes with coincident genetic alterations, correlated gene dosage (the copy number for a specific gene determined by certain analytic approaches) and gene expression, and multiple functional interactions; and the association between those genes and patient survival.

The researchers found: "The alteration of multiple networking genes by recurrent chromosomal aberrations in gliomas deregulates critical signaling pathways through multiple, cooperative mechanisms. These mutations, which are likely due to nonrandom selection of a distinct genetic landscape [a consistent pattern of chromosomal alterations] during gliomagenesis, are associated with patient prognosis."

The authors add that the identification of such gene alterations in gliomas prompts evaluation of their potential as therapeutic targets. "The network context of a gene likely affects the efficacy of therapies that target its protein. The complexity of our landscape model helps explain the lack of therapeutic efficacy of strategies targeting single gene products."

A multigene risk scoring model based on seven landscape genes was associated with the duration of overall survival in 189 glioblastoma patients from TCGA, an association that was confirmed in three additional malignant glioma patient populations.

"The current work provides a network model and biological rationale for the selection of a nonrandom genetic landscape in human gliomas," the authors write. "A multigene predictor model incorporating 7 landscape genes demonstrates how molecular insights emerging from our integrative multidimensional analysis could translate into relevant clinical end points affecting the future management of gliomas."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bredel et al. A Network Model of a Cooperative Genetic Landscape in Brain Tumors. JAMA The Journal of the American Medical Association, 2009; 302 (3): 261 DOI: 10.1001/jama.2009.997

Cite This Page:

JAMA and Archives Journals. "Network Of Altered Genes Appear To Play Role In Development Of Brain Tumors." ScienceDaily. ScienceDaily, 21 July 2009. <www.sciencedaily.com/releases/2009/07/090714165043.htm>.
JAMA and Archives Journals. (2009, July 21). Network Of Altered Genes Appear To Play Role In Development Of Brain Tumors. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2009/07/090714165043.htm
JAMA and Archives Journals. "Network Of Altered Genes Appear To Play Role In Development Of Brain Tumors." ScienceDaily. www.sciencedaily.com/releases/2009/07/090714165043.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins