Featured Research

from universities, journals, and other organizations

Short- And Long-term Success Of Male To Female Kidney Transplants

Date:
July 29, 2009
Source:
American Society of Nephrology
Summary:
Female recipients of kidneys from deceased male donors demonstrate an increased risk of allograft failure in the first year after transplant, but show no increased risk after ten years, according to a new study. The study authors note that proteins on male donor cells may affect the short term success of kidney transplants in women.

Female recipients of kidneys from deceased male donors demonstrate an increased risk of allograft failure in the first year after transplant, but show no increased risk after ten years, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. The study authors note that proteins on male donor cells may affect the short term success of kidney transplants in women.

Joseph Kim, MD (Toronto General Hospital and the University of Toronto, Canada) and John Gill, MD (St. Paul's Hospital and the University of British Columbia, Canada) studied information on all adult recipients of deceased-donor kidney transplants from 1990 through 2004 in the United States Renal Data System (a system that collects, analyzes, and distributes information about end-stage renal disease in the United States). 117,877 patients were followed for at least one year post transplant. Of these, 16,135 experienced kidney graft failure and 6,878 died within the year. 97,906 patients had functioning grafts at 1-year and were followed for up to 10 years post-transplant. Of these, 35,084 graft failures and 22,566 deaths occurred.

The results of this analysis indicate that H-Y antigens, derived from the male chromosome and not found in women, may elicit an immune response in women who receive transplants from deceased male donors. Compared with all other sex combinations, female recipients of male donor kidneys had a 12% increased risk for transplant failure at one year but no excess risk at 10 years. Women who received male donor kidneys also exhibited a similar increased risk of death in the first year, but no increased risk at 10 years.

Dr. Kim noted that there are numerous factors that contribute to the success of kidney transplants and that transplanting male kidneys into female recipients often produces excellent outcomes. According to the authors, many important factors should be taken into account when considering transplant options, and "future research should examine the potential mechanisms underlying the H-Y effect in order to better understand the specific role of minor histocompatibility antigens in determining kidney allograft outcomes."


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. H-Y Incompatibility Predicts Short-Term Outcomes for Kidney Transplant Recipients. Journal of the American Society of Nephrology, (in press) DOI: 10.1681/ASN.2008101110

Cite This Page:

American Society of Nephrology. "Short- And Long-term Success Of Male To Female Kidney Transplants." ScienceDaily. ScienceDaily, 29 July 2009. <www.sciencedaily.com/releases/2009/07/090729121601.htm>.
American Society of Nephrology. (2009, July 29). Short- And Long-term Success Of Male To Female Kidney Transplants. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/07/090729121601.htm
American Society of Nephrology. "Short- And Long-term Success Of Male To Female Kidney Transplants." ScienceDaily. www.sciencedaily.com/releases/2009/07/090729121601.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins