Featured Research

from universities, journals, and other organizations

Epigenetic Signature Changes In Low Oxygen Levels May Contribute To Prostate Cancer Development

Date:
August 2, 2009
Source:
UCD Conway Institute of Biomolecular & Biomedical Research
Summary:
Researchers have characterized epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumor development. The results of the study may provide important targets for the early detection and manipulation of prostate cancer.

UCD Conway researchers have characterised epigenetic signature changes in prostate cells under conditions of low oxygen levels that may lead to tumour development. The results of the study published this month in the scientific journal, Human Molecular Genetics may provide important targets for the early detection and manipulation of prostate cancer.

Chronic hypoxia, or low tissue oxygen levels, is a natural feature of the aging prostate either due to declining blood flow to the area or local consumption of oxygen during re-modelling of the organ. It may also be a risk factor in the development of prostate cancer but, to date, the processes involved are not defined.

This study led by Conway Fellow, Dr Amanda McCann, and involving collaborators in UCD Conway Institute as well as teams in St Vincent’s University Hospital, the National Centre for Medical Genetics Crumlin and Cancer Research UK Cambridge Research Institute, examined the consequences of chronic hypoxia on prostate cells.

Epigenetic gene regulation refers to changes in gene expression caused by mechanisms other than changes in the underlying DNA sequence. The group found significant epigenetic and cellular alterations in prostate cells as a result of hypoxia. Cells became more resistant to the natural process of cell death, increasingly able to migrate or invade and also caused the secretion of chemical messengers that are believed to be involved in the growth and survival of prostate tumour cells.

Epigenetic alterations were also identified across the extent of the genome and involved increased histone acetylation and DNA methylation. These epigenetic processes may promote and maintain the expression of regulatory genes and activation of adaptive pathways that possibly promote tumour development.

Commenting on the significance of the findings, Dr Jenny Watson PhD, a Health Research Board North/South funded postdoctoral scientist and lead author on the publication, said, “Understanding how chronic hypoxia influences global and gene-specific epigenetic programming will provide important insights into the mechanisms of hypoxia-induced cellular changes. The identification of these factors contributing to the initial development of prostate cancer represents important targets for early detection and manipulation in early stage disease”.

This research was funded by the Health Research Board in Ireland [HRB NS/2004/2] and the UCD Horizon Scanning Seed funding scheme.


Story Source:

The above story is based on materials provided by UCD Conway Institute of Biomolecular & Biomedical Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Watson et al. Generation of an epigenetic signature by chronic hypoxia in prostate cells. Human Molecular Genetics, 2009; DOI: 10.1093/hmg/ddp307

Cite This Page:

UCD Conway Institute of Biomolecular & Biomedical Research. "Epigenetic Signature Changes In Low Oxygen Levels May Contribute To Prostate Cancer Development." ScienceDaily. ScienceDaily, 2 August 2009. <www.sciencedaily.com/releases/2009/07/090730073919.htm>.
UCD Conway Institute of Biomolecular & Biomedical Research. (2009, August 2). Epigenetic Signature Changes In Low Oxygen Levels May Contribute To Prostate Cancer Development. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/07/090730073919.htm
UCD Conway Institute of Biomolecular & Biomedical Research. "Epigenetic Signature Changes In Low Oxygen Levels May Contribute To Prostate Cancer Development." ScienceDaily. www.sciencedaily.com/releases/2009/07/090730073919.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins