Featured Research

from universities, journals, and other organizations

'Regulatory' Genetic Sequences May Predict Risk For Prostate Cancer

Date:
August 18, 2009
Source:
University of Southern California
Summary:
Researchers have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.

Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.

The findings, published today in the Public Library of Science (PLoS) Genetics journal, found mechanisms involved in cancer-associated sites in areas where no genes are present (gene 'deserts') at a chromosomal region called 8q24. The new findings show that some of these sites have embedded regulatory sequences that act as enhancers of gene expression, modulated by genetic variation, or single nucleotide polymorphisms (SNPs).

The two-year study, conducted by researchers from USC, Harvard University and the Weizmann Institute of Tel Aviv, Israel, found novel functions of SNPs in areas where no genes were present. They found how the SNPs are able to modulate genetic expression even while they were near no genes. SNPs denote a modest increase in risk for certain diseases; in this particular chromosomal area, the SNPs appear to be influencing gene expression for prostate (and other) cancer 'at a genetic distance'.

"The real contribution of this discovery is that we get a feel for a previously unappreciated mechanism that may be a predisposition to this disease," said Gerhard (Gerry) Coetzee, Ph.D., professor of urology and preventive medicine at the Keck School of Medicine and principal investigator on the study. "We have unearthed a new way to understand the risk for prostate cancer."

The study was prompted by discrepancies in prostate cancer risk among ethnic groups. Currently, risk factors for prostate cancer are governed by age, and a disproportionate increased risk chiefly among African-American men, with Caucasian men following and Asian men last. This gene 'desert' featuring versions of particular SNPs are found more often in African-American men and may explain their increased risk for the disease.

The National Cancer Institute and the L.K.Whittier Foundation funded the study.


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Journal Reference:

  1. Li Jia, Gilad Landan, Mark Pomerantz, Rami Jaschek, Paula Herman, David Reich, Chunli Yan, Omar Khalid, Phil Kantoff, William Oh, J. Robert Manak, Benjamin P Berman, Brian E Henderson, Baruch Frenkel, Christopher A Haiman, Matthew Freedman, Amos Tanay, Gerhard A Coetzee. Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus. PLoS Genetics, 2009; DOI: 10.1371/journal.pgen.1000597

Cite This Page:

University of Southern California. "'Regulatory' Genetic Sequences May Predict Risk For Prostate Cancer." ScienceDaily. ScienceDaily, 18 August 2009. <www.sciencedaily.com/releases/2009/08/090814165259.htm>.
University of Southern California. (2009, August 18). 'Regulatory' Genetic Sequences May Predict Risk For Prostate Cancer. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/08/090814165259.htm
University of Southern California. "'Regulatory' Genetic Sequences May Predict Risk For Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090814165259.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins