Featured Research

from universities, journals, and other organizations

Merkel Cell Polyomavirus Associated With Rare Skin Cancer, Merkel Cell Carcinoma

Date:
September 25, 2009
Source:
Journal of the National Cancer Institute
Summary:
The Merkel cell polyomavirus is the only human polyomavirus known to be associated with a rare skin cancer, known as Merkel cell carcinoma, according to a new study.

The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be associated with a rare skin cancer, known as Merkel cell carcinoma, according to a new study published online September 23 in the Journal of the National Cancer Institute.

Related Articles


The majority of patients with Merkel cell carcinoma carry MCPyV, but little is known about the polyomavirus' prevalence in the general population and the association between circulating antibodies against MCPyV and the rare skin cancer.

Denise A. Galloway, Ph.D. and Paul Nghiem, M.D., Ph.D., of Fred Hutchinson Cancer Research Center in Seattle, and colleagues investigated the levels of antibodies against all five human polyomaviruses in plasma from 41 patients with Merkel cell carcinoma and 76 matched control subjects. Seroprevalence of polyomavirus-specific antibodies for McPyV and the other four polyomaviruses—BK, JC, WU, and KI—was also determined in another 451 control subjects, who represented the general population. MCPyV DNA was determined in tumor tissue specimens.

The authors found that 36 (88%) of 41 patients with Merkel cell carcinoma carried antibodies against MCPyV compared with 40 (53%) of the 76 control subjects. MCPyV DNA was detectable in 24 (77%) of the 31 Merkel cell carcinoma tumors available, with 22 (92%) of these 24 patients also carrying antibodies against MCPyV. Among the 451 control subjects, prevalence of antibodies against the five human polyomaviruses was 92% for BK virus, 45% for JC virus, 98% for WU polyomavirus, 90% for KI polyomavirus, and 59% for MCPyV.

Although infection with MCPyV is common in the general population, MCPyV, but not the other four human polyomaviruses, appears to be associated with Merkel cell carcinoma.

"It should be remembered that Merkel cell cancer is rare…," the authors write. "Thus, although antibody reactivity against MCPyV was associated with an increased risk of developing cell cancer, the absolute risk of cancer development in antibody–positive individuals is exceeding low."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Merkel Cell Polyomavirus Associated With Rare Skin Cancer, Merkel Cell Carcinoma." ScienceDaily. ScienceDaily, 25 September 2009. <www.sciencedaily.com/releases/2009/09/090923163846.htm>.
Journal of the National Cancer Institute. (2009, September 25). Merkel Cell Polyomavirus Associated With Rare Skin Cancer, Merkel Cell Carcinoma. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2009/09/090923163846.htm
Journal of the National Cancer Institute. "Merkel Cell Polyomavirus Associated With Rare Skin Cancer, Merkel Cell Carcinoma." ScienceDaily. www.sciencedaily.com/releases/2009/09/090923163846.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins