Featured Research

from universities, journals, and other organizations

Scientist Builds Imager That Identifies, Locates Individual Cancer Cells

Date:
October 4, 2009
Source:
Case Western Reserve University
Summary:
A biomedical engineer has spent the last four years building a better imager for preclincal studies. He can now disassemble a specimen and reassemble it into a three-dimensional digital model that gives details down to single cells and their exact location.

Image of cancer cells, labeled with green fluorescent protein, in the adrenal gland of a mouse.
Credit: Dave Wilson et al. / Image courtesy of Case Western Reserve University

Dave Wilson was dissatisfied with blurry, low-sensitivity optical images of diseased tissues. So, four years ago he set out to create a better imager.

Related Articles


Now, Wilson, a professor of biomedical engineering at Case Western Reserve University, can identify a single cancer cell in preclinical imaging studies. And he can pinpoint exactly where the cell is located in a three-dimensional image.

Called cryo-imaging, the system enables Wilson and collaborators to identify single molecules, count the number of cells in an organ, compare a normal heart to an abnormal heart and more. The incredibly detailed images can show the effectiveness of different drug therapies, gene therapies and cellular therapies in preclinical testing, Wilson said.

The cryo-imaging system literally disassembles real tissue layer by layer then reassembles the details into a cyber model.

"You can't meet this resolution from outside the body," Wilson said.

In a paper published in the Annals of Biomedical Engineering, Wilson and co-authors describe cryo-imaging and the extensive software they wrote to enable them to zero in on single cells.

The images are in color, which provides more detail than the gray scale used in other devices, such as Magnetic Resonance Imaging, he said.

In this specific model, the software assembled images of the internal organs, showing the location of individual metastatic cancer cells in the adrenal gland.

If you're only interested in the central nervous system, the vascular system or something less than a complete specimen, the imager has the capability of giving you exactly what you want, Wilson said. As the computer assembles the images, it sends text message updates to researchers.

James Basilion, an associate professor of radiology and biomedical engineering at Case Western Reserve, did not work on Wilson's imager but has seen the results.

"This device provides superb resolution and sensitivity to identify fluorogenic compounds or cells virtually anywhere within a specimen," Basilion said. "No longer do we need to 'guess' which cells are taking up agents from radiological biodistribution studies. We now can visualize them."

Wilson launched his research with a Third Frontier grant from the state of Ohio. As he made progress, he was funded with about $1.5 million in grants from the National Institutes of Health. He has founded a start-up company, called BioInVision Inc., in Mayfield Village, Ohio, to commercialize the imaging system.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Scientist Builds Imager That Identifies, Locates Individual Cancer Cells." ScienceDaily. ScienceDaily, 4 October 2009. <www.sciencedaily.com/releases/2009/09/090928131026.htm>.
Case Western Reserve University. (2009, October 4). Scientist Builds Imager That Identifies, Locates Individual Cancer Cells. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2009/09/090928131026.htm
Case Western Reserve University. "Scientist Builds Imager That Identifies, Locates Individual Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2009/09/090928131026.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins