Featured Research

from universities, journals, and other organizations

New Knowledge About Bone Marrow Transplants Can Help Leukemia Patients

Date:
October 1, 2009
Source:
The Swedish Research Council
Summary:
Acute lymphatic leukemia is the most common form of blood cancer in children. Even though chemotherapy is improving, the cancer often returns. New research shows that cancer cells that have been exposed to chemotherapy and survived are less vulnerable to chemotherapy, and more aggressive as well. But this research also yielded discoveries that should be able to enhance our treatment of the disease.

Acute lymphatic leukemia is the most common form of blood cancer in children. Even though chemotherapy is improving, the cancer often returns. Johan Jansson’s research at Kalmar University in Sweden shows that cancer cells that have been exposed to chemotherapy and survived are less vulnerable to chemotherapy, and more aggressive as well. But this research also yielded discoveries that should be able to enhance our treatment of the disease.

Related Articles


Johan Jansson’s research shows that leukemia cells that have been exposed to chemotherapy and survived did not develop resistance against bone marrow transplants from a sibling, for example. At the same time, however, several important changes were observed in these cancer cells. On the one hand, they were less vulnerable to chemotherapy and, on the other, their growth rate increased.

Johan Jansson also identified several immunologically important genes that either increased or decreased when they had been exposed to a bone marrow transplant. Three of these genes were especially interesting in that they were involved in activating the immune defense and the killing of cancer cells. It was also shown that such a bone marrow transplant could have an inhibiting effect on the leukemia cells that also proved to be able to activate parts of the immune defense.

Finally, Johan Jansson studied whether it is possible to check the leukemia cells that remain after a bone marrow transplant. This was done by vaccinating mice with a mixture of ‘dead’ leukemia cells and immune cells from a donor. It was observed that the immune defense was activated to some degree, but that the mice did not live any longer as a result. On the other hand, it was seen that these mice had B cells that produced antibodies against leukemia cells. This knowledge could be further elaborated to develop and enhance the effects of a bone marrow transplant.


Story Source:

The above story is based on materials provided by The Swedish Research Council. Note: Materials may be edited for content and length.


Cite This Page:

The Swedish Research Council. "New Knowledge About Bone Marrow Transplants Can Help Leukemia Patients." ScienceDaily. ScienceDaily, 1 October 2009. <www.sciencedaily.com/releases/2009/09/090930102721.htm>.
The Swedish Research Council. (2009, October 1). New Knowledge About Bone Marrow Transplants Can Help Leukemia Patients. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2009/09/090930102721.htm
The Swedish Research Council. "New Knowledge About Bone Marrow Transplants Can Help Leukemia Patients." ScienceDaily. www.sciencedaily.com/releases/2009/09/090930102721.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins