Featured Research

from universities, journals, and other organizations

Key Behavior Of Immune Response To Listeria Identified

Date:
October 6, 2009
Source:
University of British Columbia
Summary:
Microbiologists have identified a key defense mechanism used by the immune system against Listeria with strong implications for the future development of vaccines.

A team of University of British Columbia microbiologists has identified a key defence mechanism used by the immune system against Listeria with strong implications for the future development of vaccines.

Listeria is the bacteria that causes listeriosis, a food-borne infection that caused 22 deaths in Canada in an August 2008 outbreak in meat products produced by Maple Leaf Foods.

"We know a great deal about how our body's adaptive immune system reacts to viruses but generally very little about immune response against bacterial infections," says Wilfred Jefferies, a professor at UBC's Michael Smith Laboratories and Biomedical Research Centre.

The study, published in the online journal PLoS ONE, focuses on dendritic cells that help activate the immune system. Dendritic cells collect pathogen materials and present them to other parts of the immune system – such as T-cells – a mechanism called cross-presentation.

The UBC team also includes post-doctoral fellows Anna Reinicke and Genc Basha and graduate student Kyla Omilusik.

"Dendritic cells are gatekeepers; they are small in numbers but very active in patrolling tissues that are in contact with the external environment, such as the skin," says Jefferies, who is also a member of the UBC Blood Research Centre, the Brain Research Centre and the Vancouver Coastal Health Research Institute.

"Their job is to apprehend the pathogens while avoiding getting infected," says Jefferies. "We've found that they achieve this by sampling bits and pieces of the bacterial pathogens in the area surrounding infected cells, instead of directly approaching the bacteria."

Their research also shows that when cross-presentation is deactivated, the host becomes severely compromised in its ability to generate the appropriate T-cells to fight the Listeria infection.

"This study establishes the vital role of dendritic cell cross-presentation in fighting bacteria infections and sheds light on how we can manipulate and engage immune responses. This knowledge will ultimately aid in the design of vaccines against bacteria and other pathogens," says Jefferies.

The study was supported by funding from The Canadian Institutes of Health Research (CIHR). "Better understanding of the body's immune system is the key to develop new strategies for treating bacterial infections and for creating new vaccines for Listeria ", says Dr. Bhagirath Singh, Scientific Director at CIHR's Institute of Infection and Immunity. "Dr. Jefferies's work advances our collective effort to prevent listerosis by focusing on the way our immune defences are wired and triggered upon initial infection by invading pathogens."


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anna T. Reinicke, Kyla D. Omilusik, Genc Basha, Wilfred A. Jefferies. Dendritic Cell Cross-Priming Is Essential for Immune Responses to Listeria monocytogenes. PLoS ONE, 2009; DOI: 10.1371/journal.pone.0007210

Cite This Page:

University of British Columbia. "Key Behavior Of Immune Response To Listeria Identified." ScienceDaily. ScienceDaily, 6 October 2009. <www.sciencedaily.com/releases/2009/10/091005210013.htm>.
University of British Columbia. (2009, October 6). Key Behavior Of Immune Response To Listeria Identified. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2009/10/091005210013.htm
University of British Columbia. "Key Behavior Of Immune Response To Listeria Identified." ScienceDaily. www.sciencedaily.com/releases/2009/10/091005210013.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins