Featured Research

from universities, journals, and other organizations

Stem Cells Which 'Fool Immune System' May Provide Vaccination For Cancer

Date:
October 8, 2009
Source:
Wiley-Blackwell
Summary:
A new study reveals the potential for human stem cells to provide a vaccination against colon cancer. This discovery builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumour response. However, this theory has never before been advanced beyond animal research so the discovery that human stem cells are able to immunize against colon cancer is both new and unexpected.

Scientists from the United States and China have revealed the potential for human stem cells to provide a vaccination against colon cancer, reports a study published in Stem Cells.

This discovery, led by experts in immunology, Dr. Bei Liu and Dr. Zihai Li, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumour response. However, this theory has never before been advanced beyond animal research so the discovery that human stem cells are able to immunize against colon cancer is both new and unexpected.

"This finding potentially opens up a new paradigm for cancer vaccine research," said Dr. Zihai Li. "Cancer and stem cells share many molecular and biological features. By immunizing the host with stem cells, we are able to 'fool' the immune system to believe that cancer cells are present and thus to initiate a tumor-combating immune program."

The research is the first of its kind to implicate the role of human stem cells in vaccinating against colon cancer, and represents collaboration between the laboratories of Dr. Zihai Li and stem cell expert Dr. Renhe Xu at the University of Connecticut Stem Cell Institute.

The team vaccinated laboratory mice with human embryonic stem (hES) cells and discovered a consistent immune response against colon cancer cells. The team witnessed dramatic decline in tumor growth within the immunized mice. This revealed that immunized mice could generate a strong anti-tumour response through the application of hES cells.

The team also discovered that while natural embryonic stem cells are able to provide a response, artificially induced pluripotent stem cells (iPSC) are not. This is significant as it challenges the theory that iPSC are the same as hES cells and may replace them at the forefront of stem cell research.

"Although we have only tested the protection against colon cancer, we believe that stem cells might be useful for generating an immune response against a broad-spectrum of cancers, thus serving as a universal cancer vaccine." " concluded Dr. Bei Liu.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Li.Y, Hui.Z, Ren-He.X, Bei.L, Z.Li. Vaccination with Human Pluripotent Stem Cells Generates A Broad Spectrum of Immunological And Clinical Response Against Colon Cancer. Stem Cells, 2009; DOI: 10.1002/stem.234

Cite This Page:

Wiley-Blackwell. "Stem Cells Which 'Fool Immune System' May Provide Vaccination For Cancer." ScienceDaily. ScienceDaily, 8 October 2009. <www.sciencedaily.com/releases/2009/10/091007223724.htm>.
Wiley-Blackwell. (2009, October 8). Stem Cells Which 'Fool Immune System' May Provide Vaccination For Cancer. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/10/091007223724.htm
Wiley-Blackwell. "Stem Cells Which 'Fool Immune System' May Provide Vaccination For Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/10/091007223724.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins