Featured Research

from universities, journals, and other organizations

ATP Is A Key To Feel Warm Temperature

Date:
October 8, 2009
Source:
National Institute for Physiological Sciences
Summary:
A Japanese research group has found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons.

A Japanese research group led by Prof. Makoto Tominaga and Dr. Sravan Mandadi (National Institute for Physiological Sciences: NIPS) found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons. Their findings were presented in the Pflόgers Archiv - European Journal of Physiology published on October 2009.

Hazardous temperatures (extreme hot or cold) are known to be detected by the temperature-activated ion channels (thermoTRPs) expressed in free sensory nerve endings. On the other hand, ambient innocuous warm temperatures are sensed by different thermoTRPs, TRPV3 and TRPV4 expressed in skin keratinocytes. Interesting question is, therefore, how our nervous system recognizes the warmth information sensed by the non-excitable epithelial cells.

In a co-culture system, heat-evoked response in DRG neurons was secondary to that in skin keratinocytes, and the DRG responses were diminished by the ATP receptor antagonists. ATP release from keratinocytes was confirmed by 'a bio-sensor system' in which a cell expressing ATP receptors was placed in close proximity to keratinocytes. Warmth-activated TRPV3, rather than TRPV4, was found to be predominantly involved in the ATP release upon heating.

Dr. Tominaga said, "Our findings for the first time explains how ambient temperature information can be sent from skin to sensory nerves. Our results also support the emerging concept of ATP-mediated information transmission in the non-synaptic connections."


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sravan Mandadi, Takaaki Sokabe, Koji Shibasaki, Kimiaki Katanosaka, Atsuko Mizuno, Aziz Moqrich, Ardem Patapoutian, Tomoko Fukumi-Tominaga, Kazue Mizumura and Makoto Tominaga. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflόgers Archiv - European Journal of Physiology, 2009; 458 (6): 1093 DOI: 10.1007/s00424-009-0703-x

Cite This Page:

National Institute for Physiological Sciences. "ATP Is A Key To Feel Warm Temperature." ScienceDaily. ScienceDaily, 8 October 2009. <www.sciencedaily.com/releases/2009/10/091008113257.htm>.
National Institute for Physiological Sciences. (2009, October 8). ATP Is A Key To Feel Warm Temperature. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/10/091008113257.htm
National Institute for Physiological Sciences. "ATP Is A Key To Feel Warm Temperature." ScienceDaily. www.sciencedaily.com/releases/2009/10/091008113257.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins