Featured Research

from universities, journals, and other organizations

DAF Protects Against Atherosclerosis

Date:
October 10, 2009
Source:
American Journal of Pathology
Summary:
Researchers have discovered that decay accelerating factor (DAF) protects against atherosclerosis.

Dr. Dorian Haskard and colleagues at the Imperial College, London, UK have discovered that decay accelerating factor (DAF) protects against atherosclerosis.

Atherosclerosis describes any hardening and loss of elasticity of the arteries due to a build-up of fatty material such as cholesterol. Activation of the complement system, which consists of a cascade of small proteins that can result in cell lysis or trigger inflammation, plays a regulatory role in atherosclerotic lesion development. However, whereas proximal members of the complement pathway have a protective role, distal components are atherogenic.

DAF regulates complement activation at the C3 (proximal) level, but its role in atherosclerotic lesion development remains unclear. Leung et al hypothesized that DAF plays a protective role in atherosclerosis. Using a DAF-deficient mouse model of atherosclerosis, they found that DAF-deficient animals had increased levels of the distal complement components C5b-9 in aortic lesions. Lesions in DAF-deficient mice had accelerated development and increased size and complexity compared with normal animals. DAF, therefore, plays an essential regulatory role in limiting complement activation on the arterial wall and is protective against atherosclerosis.

This study by Leung et al "underlines the importance of DAF in shielding the arterial wall from the atherogenic effects of complement."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leung et al. Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. American Journal Of Pathology, 2009; 175 (4): 1757 DOI: 10.2353/ajpath.2009.090183

Cite This Page:

American Journal of Pathology. "DAF Protects Against Atherosclerosis." ScienceDaily. ScienceDaily, 10 October 2009. <www.sciencedaily.com/releases/2009/10/091010120753.htm>.
American Journal of Pathology. (2009, October 10). DAF Protects Against Atherosclerosis. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2009/10/091010120753.htm
American Journal of Pathology. "DAF Protects Against Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2009/10/091010120753.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins