Featured Research

from universities, journals, and other organizations

Inhibiting The Cellular Process Autophagy Makes Mice Leaner

Date:
December 21, 2009
Source:
Journal of Clinical Investigation
Summary:
The more brown fat cells a person has, the lower their body mass. Therefore, manipulating the development of fat cells so that they become brown fat cells rather than white fat cells might be an approach to treat obesity. Researchers have now identified a cellular process that regulates the formation of the distinct fat cell types in mice. This process is known as autophagy.

Recent data have indicated that the more brown fat cells a person has the lower their body mass. This contrasts with what is known for white fat cells, the more white fat cells a person has the greater their body mass. It has been suggested that manipulating the development of fat cells so that they become brown fat cells rather than white fat cells might be an approach to treat obesity.

However, before such an approach can be developed more needs to be learned about the mechanisms regulating the formation, expansion, and interconversion of these two cell types.

New research, performed by Mark Czaja and colleagues, at Albert Einstein College of Medicine, New York, has now identified a cellular process that regulates the formation of the distinct fat cell types in mice. The research appears in the Journal of Clinical Investigation.

Specifically, in mice with fat cells unable to perform the cellular process known as autophagy, there were fewer white fat cells and more brown fat cells than normal. Further, these mice were leaner than normal.

The authors therefore conclude that autophagy has a critical role in determining the type of fat cell formed and suggest that this information might provide a new avenue to explore for those looking to develop therapies to treat obesity.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Singh et al. Autophagy regulates adipose mass and differentiation in mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39228

Cite This Page:

Journal of Clinical Investigation. "Inhibiting The Cellular Process Autophagy Makes Mice Leaner." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com/releases/2009/10/091012225803.htm>.
Journal of Clinical Investigation. (2009, December 21). Inhibiting The Cellular Process Autophagy Makes Mice Leaner. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2009/10/091012225803.htm
Journal of Clinical Investigation. "Inhibiting The Cellular Process Autophagy Makes Mice Leaner." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012225803.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins