Featured Research

from universities, journals, and other organizations

Inhibiting The Cellular Process Autophagy Makes Mice Leaner

Date:
December 21, 2009
Source:
Journal of Clinical Investigation
Summary:
The more brown fat cells a person has, the lower their body mass. Therefore, manipulating the development of fat cells so that they become brown fat cells rather than white fat cells might be an approach to treat obesity. Researchers have now identified a cellular process that regulates the formation of the distinct fat cell types in mice. This process is known as autophagy.

Recent data have indicated that the more brown fat cells a person has the lower their body mass. This contrasts with what is known for white fat cells, the more white fat cells a person has the greater their body mass. It has been suggested that manipulating the development of fat cells so that they become brown fat cells rather than white fat cells might be an approach to treat obesity.

Related Articles


However, before such an approach can be developed more needs to be learned about the mechanisms regulating the formation, expansion, and interconversion of these two cell types.

New research, performed by Mark Czaja and colleagues, at Albert Einstein College of Medicine, New York, has now identified a cellular process that regulates the formation of the distinct fat cell types in mice. The research appears in the Journal of Clinical Investigation.

Specifically, in mice with fat cells unable to perform the cellular process known as autophagy, there were fewer white fat cells and more brown fat cells than normal. Further, these mice were leaner than normal.

The authors therefore conclude that autophagy has a critical role in determining the type of fat cell formed and suggest that this information might provide a new avenue to explore for those looking to develop therapies to treat obesity.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Singh et al. Autophagy regulates adipose mass and differentiation in mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39228

Cite This Page:

Journal of Clinical Investigation. "Inhibiting The Cellular Process Autophagy Makes Mice Leaner." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com/releases/2009/10/091012225803.htm>.
Journal of Clinical Investigation. (2009, December 21). Inhibiting The Cellular Process Autophagy Makes Mice Leaner. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/10/091012225803.htm
Journal of Clinical Investigation. "Inhibiting The Cellular Process Autophagy Makes Mice Leaner." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012225803.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins