Featured Research

from universities, journals, and other organizations

Immune Cells Predict Outcome Of West Nile Virus Infection

Date:
October 16, 2009
Source:
Journal of Clinical Investigation
Summary:
Infection with West Nile virus (WNV) causes no symptoms in most people. However, it can cause fever, meningitis, and/or encephalitis. Researchers now report that levels of immune cells known as Tregs (immune cells that suppress the function of other immune cells) in the blood of a human or mouse infected with WNV predict whether the person or mouse will have symptoms of infection.

Infection with West Nile virus (WNV) causes no symptoms in most people. However, it can cause fever, meningitis, and/or encephalitis. What determines the outcome of infection with WNV in different people has not been determined.

But now, Philip Norris and colleagues, at the Blood Systems Research Institute, San Francisco, have found that levels of immune cells known as Tregs (immune cells that suppress the function of other immune cells) in the blood of a human or mouse infected with WNV predict whether the person or mouse will have symptoms of infection.

The research appears in the Journal of Clinical Investigation.

In the study, analysis of blood donated by 32 individuals acutely infected with WNV indicated that the frequency of Tregs increased substantially following infection. However, those individuals that were asymptomatic had higher levels of Tregs than those that exhibited symptoms of infection. Similar observations were made in mice infected with WNV. Consistent with a role for Tregs in controlling the symptoms of WNV infection, mice lacking Tregs were more susceptible to lethal infection with WNV than control mice.

The authors therefore conclude that higher levels of Tregs in the blood after infection with WNV protect against severe disease in individuals with a fully functioning immune system.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lanteri et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39387

Cite This Page:

Journal of Clinical Investigation. "Immune Cells Predict Outcome Of West Nile Virus Infection." ScienceDaily. ScienceDaily, 16 October 2009. <www.sciencedaily.com/releases/2009/10/091012225805.htm>.
Journal of Clinical Investigation. (2009, October 16). Immune Cells Predict Outcome Of West Nile Virus Infection. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/10/091012225805.htm
Journal of Clinical Investigation. "Immune Cells Predict Outcome Of West Nile Virus Infection." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012225805.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins