Featured Research

from universities, journals, and other organizations

Immune Cells Predict Outcome Of West Nile Virus Infection

Date:
October 16, 2009
Source:
Journal of Clinical Investigation
Summary:
Infection with West Nile virus (WNV) causes no symptoms in most people. However, it can cause fever, meningitis, and/or encephalitis. Researchers now report that levels of immune cells known as Tregs (immune cells that suppress the function of other immune cells) in the blood of a human or mouse infected with WNV predict whether the person or mouse will have symptoms of infection.

Infection with West Nile virus (WNV) causes no symptoms in most people. However, it can cause fever, meningitis, and/or encephalitis. What determines the outcome of infection with WNV in different people has not been determined.

But now, Philip Norris and colleagues, at the Blood Systems Research Institute, San Francisco, have found that levels of immune cells known as Tregs (immune cells that suppress the function of other immune cells) in the blood of a human or mouse infected with WNV predict whether the person or mouse will have symptoms of infection.

The research appears in the Journal of Clinical Investigation.

In the study, analysis of blood donated by 32 individuals acutely infected with WNV indicated that the frequency of Tregs increased substantially following infection. However, those individuals that were asymptomatic had higher levels of Tregs than those that exhibited symptoms of infection. Similar observations were made in mice infected with WNV. Consistent with a role for Tregs in controlling the symptoms of WNV infection, mice lacking Tregs were more susceptible to lethal infection with WNV than control mice.

The authors therefore conclude that higher levels of Tregs in the blood after infection with WNV protect against severe disease in individuals with a fully functioning immune system.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lanteri et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39387

Cite This Page:

Journal of Clinical Investigation. "Immune Cells Predict Outcome Of West Nile Virus Infection." ScienceDaily. ScienceDaily, 16 October 2009. <www.sciencedaily.com/releases/2009/10/091012225805.htm>.
Journal of Clinical Investigation. (2009, October 16). Immune Cells Predict Outcome Of West Nile Virus Infection. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/10/091012225805.htm
Journal of Clinical Investigation. "Immune Cells Predict Outcome Of West Nile Virus Infection." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012225805.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins