Featured Research

from universities, journals, and other organizations

Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model

Date:
November 20, 2009
Source:
Public Library of Science
Summary:
New research challenges the dogma of the antibody-dependent enhancement model for the development of dengue hemorrhagic fever.

Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF).

Dengue virus infection usually causes a severe 'flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial ''primary'' dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the 'antibody-dependent enhancement' model).

A prospective nested case-control study of infant dengue carried out by Daniel Libraty (of the University of Massachusetts Medical School, Worcester, MA) and colleagues reveals that maternal antibodies against dengue protect infants from the full spectrum of dengue disease. They also found that all infants with symptomatic dengue virus infection had antibodies with measurable ADE activity, but that there was no link between the amount of ADE activity and the development of DHF. They failed to find evidence supporting a role for the ADE model of development of DHF but did find that a higher weight-for-age was a risk factor for DHF.

The authors conclude that 'the results should encourage a rethinking or refinement of the currently promulgated ADE model for infant DHF, promote prospective studies of infant dengue and stimulate new directions of research into novel potential mechanisms for infant DHF'.

This study was supported by National Institutes of Health grant U01 AI065654.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Libraty et al. A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever Model. PLoS Medicine, 2009; 6 (10): e1000171 DOI: 10.1371/journal.pmed.1000171

Cite This Page:

Public Library of Science. "Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model." ScienceDaily. ScienceDaily, 20 November 2009. <www.sciencedaily.com/releases/2009/10/091026220005.htm>.
Public Library of Science. (2009, November 20). Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/10/091026220005.htm
Public Library of Science. "Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model." ScienceDaily. www.sciencedaily.com/releases/2009/10/091026220005.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins