Featured Research

from universities, journals, and other organizations

Researchers Find Brain Cell Transplants Help Repair Neural Damage

Date:
October 30, 2009
Source:
Cell Transplantation Center of Excellence for Aging and Brain Repair
Summary:
A study aimed at determining whether autografted cells derived from primate cortical gray matter, cultured for one month and re-implanted in the caudate nucleus of dopamine depleted primates, effectively survived and migrated. When transplanted, autologous cells, derived from the most dopamine depleted region of the caudate nucleus, migrated, re-implanted into the right caudate nucleus, and migrated through the corpus callosum to the contralateral striatum. Re-implanted cells survived at rate of 50 percent four months post-implantation.

A Swiss research team has found that using an animal's own brain cells (autologous transplant) to replace degenerated neurons in select brain areas of donor primates with simulated but asymptomatic Parkinson's disease and previously in a motor cortex lesion model, provides a degree of brain protection and may be useful in repairing brain lesions and restoring function.

"We aimed at determining whether autografted cells derived from cortical gray matter, cultured for one month and re-implanted in the caudate nucleus of dopamine depleted primates, effectively survived and migrated," said Dr. Jean-Francoise Brunet who, along with colleagues, published their study in Cell Transplantation. "The autologous, re-implanted cells survived at an impressively high rate of 50 percent for four months post-implantation."

While the use of neural grafts to restore function after lesions or degeneration of the central nervous system has been widely reported, the objective of this study was to replace depleted neurons to a restricted brain area and to avoid both the ethical controversies accompanying fetal cell transplants as well as immune rejection.

Researchers found that the cultured cells migrated, re-implanted into the right caudate nucleus, and migrated through the corpus callosum to the contralateral striatum. Most of the cells were found in the most dopamine depleted region of the caudate nucleus. This study replicated in primates the success the research team had previously reported using laboratory mice.

According to the researchers, the cultured cells exhibited neural progenitor characteristics that could make them useful for brain repair.

"Our results confirm that adult brain cells can be obtained, cryopreserved and kept in culture before being re-implanted in the donor where they survive in vivo for at least four months," concluded Dr. Brunet and colleagues. The study has drawn considerable interest in the transplantation community. "This is an extremely important finding because although we have known for many years that fetal cells can be used to replace damaged neurons their limited availability has prevented widespread use in clinical settings," commented Section Editor Dr. John Sladek, professor of pediatrics and neuroscience at the University of Colorado School of Medicine.


Story Source:

The above story is based on materials provided by Cell Transplantation Center of Excellence for Aging and Brain Repair. Note: Materials may be edited for content and length.


Cite This Page:

Cell Transplantation Center of Excellence for Aging and Brain Repair. "Researchers Find Brain Cell Transplants Help Repair Neural Damage." ScienceDaily. ScienceDaily, 30 October 2009. <www.sciencedaily.com/releases/2009/10/091029102427.htm>.
Cell Transplantation Center of Excellence for Aging and Brain Repair. (2009, October 30). Researchers Find Brain Cell Transplants Help Repair Neural Damage. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/10/091029102427.htm
Cell Transplantation Center of Excellence for Aging and Brain Repair. "Researchers Find Brain Cell Transplants Help Repair Neural Damage." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029102427.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins