Featured Research

from universities, journals, and other organizations

New Tool Promises More Accurate Antimalarial Drug Dosing

Date:
October 29, 2009
Source:
Liverpool School of Tropical Medicine
Summary:
Scientists have designed a tool to support the development of appropriate age-based dosing regimens for malaria drugs. Weight-based dosing is challenging in many malaria endemic countries because access to formal health services is limited, functioning scales may be scarce and many treatments are given at home using antimalarials bought from shops and street vendors. In these settings, drug doses are calculated using a patient's age to estimate their body weight.

A new tool has been designed to support the development of appropriate age-based dosing regimens for malaria drugs.
Credit: Image courtesy of Liverpool School of Tropical Medicine

Scientists at LSTM have designed a tool to support the development of appropriate age-based dosing regimens for malaria drugs. Weight-based dosing is challenging in many malaria endemic countries because access to formal health services is limited, functioning scales may be scarce and many treatments are given at home using antimalarials bought from shops and street vendors. In these settings, drug doses are calculated using a patient's age to estimate their body weight.

There are no standardised procedures to devise age-based regimens as part of the normal regulatory drug developmental process, yet malaria control programs need dose recommendations that are based on both weight and age. The lack of clear guidance on age-based dosing has resulted in a considerable variation in recommendations, potentially resulting in poor, but widely-used regimens.

The method developed by LSTM's Dr Anja Terlouw and colleagues in collaboration with the World Health Organisation TDR programme, the Drugs for Neglected Diseases Initiative (DNDi) and the Netherlands Organisation for Applied Scientific Research helps to determine appropriate age-based dose regimens for both children and adolescents that would result in the smallest number of patients receiving doses above or below the effective dose range.

"A weight-for-age reference data set was compiled and modelled specifically for this purpose using nutritional data that was shared with us by institutes and scientists from over 35 malaria endemic countries. This allowed us to develop a modelled reference distribution that reflects the variation in weight by age of populations in malaria endemic regions of Africa, Asia Pacific and Latin America and can therefore provide the optimal translation of weight-based to age-based dosing regimens," explained Dr Anja Terlouw.

It has become increasingly clear that there are similar needs for age-based dosing regimens with other drugs. To address this, the team from LSTM has started work with DNDi and others to explore practical opportunities for work on drugs for other neglected diseases and to improve the availability of evidence-based, safe and effective age-based dosing regimens for populations with limited access to health care.


Story Source:

The above story is based on materials provided by Liverpool School of Tropical Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Liverpool School of Tropical Medicine. "New Tool Promises More Accurate Antimalarial Drug Dosing." ScienceDaily. ScienceDaily, 29 October 2009. <www.sciencedaily.com/releases/2009/10/091029102434.htm>.
Liverpool School of Tropical Medicine. (2009, October 29). New Tool Promises More Accurate Antimalarial Drug Dosing. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/10/091029102434.htm
Liverpool School of Tropical Medicine. "New Tool Promises More Accurate Antimalarial Drug Dosing." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029102434.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins