Featured Research

from universities, journals, and other organizations

New Tool Promises More Accurate Antimalarial Drug Dosing

Date:
October 29, 2009
Source:
Liverpool School of Tropical Medicine
Summary:
Scientists have designed a tool to support the development of appropriate age-based dosing regimens for malaria drugs. Weight-based dosing is challenging in many malaria endemic countries because access to formal health services is limited, functioning scales may be scarce and many treatments are given at home using antimalarials bought from shops and street vendors. In these settings, drug doses are calculated using a patient's age to estimate their body weight.

A new tool has been designed to support the development of appropriate age-based dosing regimens for malaria drugs.
Credit: Image courtesy of Liverpool School of Tropical Medicine

Scientists at LSTM have designed a tool to support the development of appropriate age-based dosing regimens for malaria drugs. Weight-based dosing is challenging in many malaria endemic countries because access to formal health services is limited, functioning scales may be scarce and many treatments are given at home using antimalarials bought from shops and street vendors. In these settings, drug doses are calculated using a patient's age to estimate their body weight.

Related Articles


There are no standardised procedures to devise age-based regimens as part of the normal regulatory drug developmental process, yet malaria control programs need dose recommendations that are based on both weight and age. The lack of clear guidance on age-based dosing has resulted in a considerable variation in recommendations, potentially resulting in poor, but widely-used regimens.

The method developed by LSTM's Dr Anja Terlouw and colleagues in collaboration with the World Health Organisation TDR programme, the Drugs for Neglected Diseases Initiative (DNDi) and the Netherlands Organisation for Applied Scientific Research helps to determine appropriate age-based dose regimens for both children and adolescents that would result in the smallest number of patients receiving doses above or below the effective dose range.

"A weight-for-age reference data set was compiled and modelled specifically for this purpose using nutritional data that was shared with us by institutes and scientists from over 35 malaria endemic countries. This allowed us to develop a modelled reference distribution that reflects the variation in weight by age of populations in malaria endemic regions of Africa, Asia Pacific and Latin America and can therefore provide the optimal translation of weight-based to age-based dosing regimens," explained Dr Anja Terlouw.

It has become increasingly clear that there are similar needs for age-based dosing regimens with other drugs. To address this, the team from LSTM has started work with DNDi and others to explore practical opportunities for work on drugs for other neglected diseases and to improve the availability of evidence-based, safe and effective age-based dosing regimens for populations with limited access to health care.


Story Source:

The above story is based on materials provided by Liverpool School of Tropical Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Liverpool School of Tropical Medicine. "New Tool Promises More Accurate Antimalarial Drug Dosing." ScienceDaily. ScienceDaily, 29 October 2009. <www.sciencedaily.com/releases/2009/10/091029102434.htm>.
Liverpool School of Tropical Medicine. (2009, October 29). New Tool Promises More Accurate Antimalarial Drug Dosing. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/10/091029102434.htm
Liverpool School of Tropical Medicine. "New Tool Promises More Accurate Antimalarial Drug Dosing." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029102434.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins