Featured Research

from universities, journals, and other organizations

High blood pressure and markers of inflammation in blood more common in offspring of parents with Alzheimer's disease

Date:
November 13, 2009
Source:
JAMA and Archives Journals
Summary:
High blood pressure, evidence of arterial disease and markers of inflammation in the blood in middle age appear more common in individuals whose parents have Alzheimer's disease than in individuals without a parental history of the condition, according to a new report.

High blood pressure, evidence of arterial disease and markers of inflammation in the blood in middle age appear more common in individuals whose parents have Alzheimer's disease than in individuals without a parental history of the condition, according to a report in the November issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Previous twin studies estimate that as much as 60 percent of the risk for Alzheimer's disease is under genetic control, according to background information in the article. Other research has identified several vascular and inflammatory risk factors in midlife that may be associated with the later transition into cognitive decline related to Alzheimer's disease.

Eric van Exel, M.D., Ph.D., of VU University Medical Center, Amsterdam, and colleagues compared some of these vascular and inflammatory factors, such as high blood pressure and levels of pro-inflammatory proteins known as cytokines in the blood, between 206 offspring of 92 families with a history of Alzheimer's disease and 200 offspring of 97 families without a parental history. Researchers measured blood pressure; obtained blood samples to assess genetic characteristics and levels of cholesterol, along with cytokines and other inflammation-related substances; and collected sociodemographic characteristics, medical history and information about diet, exercise and stress levels.

More individuals whose parents had Alzheimer's disease carried the APOE ε4 gene, known to be associated with the condition, than did those with no family history (47 percent vs. 21 percent). In addition, those with a family history had higher systolic (top number) and diastolic (bottom number) blood pressures, a lower ankle brachial index (ratio of ankle to arm systolic blood pressure, a sign of artery disease) and higher levels of several different pro-inflammatory cytokines.

Other cardiovascular risk factors -- such as high blood cholesterol and glucose levels -- were not associated with parental Alzheimer's disease. These other components may not be as closely linked to cognitive decline, the authors write.

"Our study shows that high blood pressure and an innate pro-inflammatory cytokine response in middle age significantly contribute to Alzheimer's disease," they continue. "As these risk factors cluster in families, it is important to realize that early interventions could prevent late-onset Alzheimer's disease. One could argue for a high-risk-prevention strategy by identifying the offspring of patients with Alzheimer's disease, screening them for hypertension and vascular factors and implementing various (non)pharmacological health measures."

This research project was supported by a grant from the National Institute of Aging, a grant from the European Union project LifeSpan and the Internationale Stichting Alzheimer Onderzoek (International Foundation for Alzheimer Research, the Netherlands).


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eric van Exel; Piet Eikelenboom; Hannie Comijs; Marijke Frolich; Johannes H. Smit; Max L. Stek; Philip Scheltens; Jan E. Eefsting; Rudi G. J. Westendorp. Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer Disease. Archives of General Psychiatry, 2009; 66 (11): 1263 DOI: 10.1001/archgenpsychiatry.2009.146

Cite This Page:

JAMA and Archives Journals. "High blood pressure and markers of inflammation in blood more common in offspring of parents with Alzheimer's disease." ScienceDaily. ScienceDaily, 13 November 2009. <www.sciencedaily.com/releases/2009/11/091102171411.htm>.
JAMA and Archives Journals. (2009, November 13). High blood pressure and markers of inflammation in blood more common in offspring of parents with Alzheimer's disease. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/11/091102171411.htm
JAMA and Archives Journals. "High blood pressure and markers of inflammation in blood more common in offspring of parents with Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2009/11/091102171411.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins