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Acetaminophen May Be Linked To Asthma In Children And Adults

Date:
November 5, 2009
Source:
American College of Chest Physicians
Summary:
New research shows that the popular pain reliever, acetaminophen, may be tied to asthma in both children and adults.
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New research shows that the widely used pain reliever acetaminophen may be associated with an increased risk of asthma and wheezing in both children and adults exposed to the drug.

Researchers from the University of British Columbia, Vancouver, BC, Canada, conducted a systematic review and metaanalysis of 19 clinical studies (total subjects=425,140) that compared the risk of asthma or wheezing with acetaminophen exposure.

The analysis showed that the pooled odds ratio (odds ratio for all studies combined) for asthma among users of acetaminophen was 1.63. The risk of asthma in children who used acetaminophen in the year prior to asthma diagnosis or in the first year of life was elevated to 1.60 and 1.47, respectively.

Furthermore, results showed a slight increase in the risk of asthma and wheezing with prenatal use of acetaminophen by mothers. Researchers speculate that acetaminophen's lack of inhibition of cyclooxygenase, the key enzyme involved in the inflammatory response of asthma, may be one explanation for the potential link between acetaminophen use and asthma.

This study is published in the November issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.


Story Source:

The above post is reprinted from materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


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American College of Chest Physicians. "Acetaminophen May Be Linked To Asthma In Children And Adults." ScienceDaily. ScienceDaily, 5 November 2009. <www.sciencedaily.com/releases/2009/11/091105084842.htm>.
American College of Chest Physicians. (2009, November 5). Acetaminophen May Be Linked To Asthma In Children And Adults. ScienceDaily. Retrieved August 27, 2015 from www.sciencedaily.com/releases/2009/11/091105084842.htm
American College of Chest Physicians. "Acetaminophen May Be Linked To Asthma In Children And Adults." ScienceDaily. www.sciencedaily.com/releases/2009/11/091105084842.htm (accessed August 27, 2015).

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