Featured Research

from universities, journals, and other organizations

Newly discovered mechanism of insulin production could lead to better treatment for diabetes

Date:
November 14, 2009
Source:
The Hebrew University of Jerusalem
Summary:
How a specific gene within the pancreas affects secretion of insulin has been discovered. The work opens the way for a new understanding of possible paths to battle diabetes and diabetes-related health problems, which are on the rise all over the world.

How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities. Their work opens the way for a new understanding of possible paths to battle diabetes and diabetes-related health problems, which are on the rise all over the world.

Blood glucose levels are tightly regulated by secretion of insulin from beta cells in the pancreas. Defective insulin secretion results in poorly regulated blood glucose levels and diabetes.

The work of the multi-national research team explored the role of LKB1, a gene involved in many cellular functions, whose role in the pancreas was not examined before. Specifically, they studied the implications of beta cell-specific loss of the LKB1 gene, using a mouse model system. They were able to show that eliminating this gene from beta cells causes the production and secretion of more insulin than normal beta cells, resulting in an enhanced response to increases in blood glucose levels.

The findings have potentially great implications for those suffering from diabetes (excessive blood sugar) due to insufficient production of insulin in the pancreas.

Since it was shown that LKB1 negatively regulates both insulin content and secretion, the way has now been opened to possible development of a novel therapy that would limit the presence of this gene in pancreas beta cells, thus enhancing insulin secretion.

The researchers involved in the project, whose findings were published recently in the journal Cell Metabolism, were led by Dr. Yuval Dor of the Institute for Medical Research Israel-Canada of the Hebrew University-Hadassah Medical School and included students Zvi Granot, Avital Swisa, Judith Magenheim and Miri Stolovitch-Rain, as well as scientists from Kobe University in Japan, and American researchers from the University of Pennsylvania, Washington University in St. Louis and Massachusetts General Hospital in Boston.


Story Source:

The above story is based on materials provided by The Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

The Hebrew University of Jerusalem. "Newly discovered mechanism of insulin production could lead to better treatment for diabetes." ScienceDaily. ScienceDaily, 14 November 2009. <www.sciencedaily.com/releases/2009/11/091112103415.htm>.
The Hebrew University of Jerusalem. (2009, November 14). Newly discovered mechanism of insulin production could lead to better treatment for diabetes. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2009/11/091112103415.htm
The Hebrew University of Jerusalem. "Newly discovered mechanism of insulin production could lead to better treatment for diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/11/091112103415.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins