Newly discovered mechanism of insulin production could lead to better treatment for diabetes

Blood glucose levels are tightly regulated by secretion of insulin from beta cells in the pancreas. Defective insulin secretion results in poorly regulated blood glucose levels and diabetes.

The work of the multi-national research team explored the role of LKB1, a gene involved in many cellular functions, whose role in the pancreas was not examined before. Specifically, they studied the implications of beta cell-specific loss of the LKB1 gene, using a mouse model system. They were able to show that eliminating this gene from beta cells causes the production and secretion of more insulin than normal beta cells, resulting in an enhanced response to increases in blood glucose levels.

The findings have potentially great implications for those suffering from diabetes (excessive blood sugar) due to insufficient production of insulin in the pancreas.

Since it was shown that LKB1 negatively regulates both insulin content and secretion, the way has now been opened to possible development of a novel therapy that would limit the presence of this gene in pancreas beta cells, thus enhancing insulin secretion.

The researchers involved in the project, whose findings were published recently in the journal Cell Metabolism, were led by Dr. Yuval Dor of the Institute for Medical Research Israel-Canada of the Hebrew University-Hadassah Medical School and included students Zvi Granot, Avital Swisa, Judith Magenheim and Miri Stolovitch-Rain, as well as scientists from Kobe University in Japan, and American researchers from the University of Pennsylvania, Washington University in St. Louis and Massachusetts General Hospital in Boston.