Featured Research

from universities, journals, and other organizations

Cancer patients and doctors report drug side effects differently

Date:
November 17, 2009
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
In clinical trials for cancer, it is standard for clinicians rather than patients to report adverse symptom side effects from treatments, such as nausea and fatigue. At present, patient self-reporting, although important, is not a well studied source of this information. A new longitudinal study finds that while clinicians' and patients' reporting of treatment side effects are very different from each other, together they provide a more complete, clinically meaningful picture of the treatment experience.

In clinical trials for cancer, it is standard for clinicians rather than patients to report adverse symptom side effects from treatments, such as nausea and fatigue. At present, patient self-reporting, although important, is not a well studied source of this information. A new longitudinal study from researchers at Memorial Sloan-Kettering Cancer Center finds that while clinicians' and patients' reporting of treatment side effects are very different from each other, together they provide a more complete, clinically meaningful picture of the treatment experience.

The research was published online November 17 in the Journal of the National Cancer Institute. Ethan Basch, MD, a medical oncologist and member of the Health Outcomes Group at Memorial Sloan-Kettering, and colleagues, led an analysis of data gathered from more than 160 advanced lung cancer patients and their clinicians. All of the patients were treated at Memorial Sloan-Kettering.

The patients, both men and women with a median age of 63, were followed from 2005 to 2006 through an average of 12 office visits. All received chemotherapy during this time. Researchers tracked six common symptoms--fatigue, pain, nausea, vomiting, diarrhea, and constipation--and compared the side effects reported by the clinicians to those reported by the patients. The clinicians reported symptoms using the standard adverse event reporting tool for oncology trials, the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE.) Patients reported symptoms using a simplified version of the same reporting tool via a computer-based system.

Patients generally reported adverse symptoms earlier, more frequently, and with greater severity than their clinicians, and their responses appeared to better reflect real-time suffering. Patient-reported symptoms were more closely related to day-to-day health status, while clinicians' reports were more predictive of significant medical events. "The perspectives of both clinicians and patients provide a more complete picture of the negative impact of treatments compared with either perspective alone," said Dr. Basch. "Clinicians bring professional training and experience to their evaluations, whereas patients are in a better position to communicate their own subjective experiences," he adds.

The findings demonstrate the value of an approach that incorporates patient self-reporting of symptoms in cancer treatment trials. Such information has the potential to help both prospective prescribers and patients in understanding the anticipated side effects of treatment.

On the basis of this research Dr. Basch said, "We need to design models in which we can capitalize on what the patient is reporting in order to understand how toxic these drugs are. Our patients add tremendous value in their reporting; and by collecting this information we can actually enhance our understanding of toxicities in a way that will aid the FDA, aid clinicians, aid researchers, and aid patients themselves when they are trying to decide whether they want to start a treatment." He added that, "patient-reported adverse symptoms should be collected in clinical trials and reported in drug labels."

Funding for this research was provided by the National Cancer Institute, the American Society of Clinical Oncology, and the Steps-for-Breath philanthropic fund of Memorial Sloan-Kettering Cancer Center.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Cancer patients and doctors report drug side effects differently." ScienceDaily. ScienceDaily, 17 November 2009. <www.sciencedaily.com/releases/2009/11/091117184533.htm>.
Memorial Sloan-Kettering Cancer Center. (2009, November 17). Cancer patients and doctors report drug side effects differently. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/11/091117184533.htm
Memorial Sloan-Kettering Cancer Center. "Cancer patients and doctors report drug side effects differently." ScienceDaily. www.sciencedaily.com/releases/2009/11/091117184533.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins