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Drug for erectile dysfunction improves heart function in young heart-disease patients

Date:
November 18, 2009
Source:
Children's Hospital of Philadelphia
Summary:
After treatment with sildenafil, heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation. Sildenafil is a drug commonly used to treat erectile dysfunction and pulmonary hypertension.
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Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

Single-ventricle defects are a collection of cardiac malformations that impair the heart's ability to pump blood. Examples include tricuspid atresia, pulmonary atresia/intact ventricular septum and hypoplastic left heart syndrome.

The Fontan operation is a procedure that redirects systemic venous blood directly to the pulmonary arteries, bypassing the heart. It is the third surgery in a staged palliation for single-ventricle heart defects.

Researchers hypothesized that sildenafil may help cardiac performance by directly improving the squeeze of the heart muscle and by allowing for better filling of the heart.

In this study, researchers randomized 28 children and young adults who had undergone the Fontan operation to receive placebo or sildenafil three times a day for 6 weeks. After a 6-week break, subjects were switched to the opposite treatment course. The researchers found significant improvement in heart performance during treatment with sildenafil.

"The enhanced heart performance may improve exercise performance and quality of life in these children and young adults," said David J. Goldberg, M.D., pediatric cardiologist at The Children's Hospital of Philadelphia, who presented the abstract on Nov. 17 at the American Heart Association Scientific Sessions in Orlando, Fla.

Grants from The Mark H. and Blanche M. Harrington Foundation and from Big Hearts to Little Hearts provided funding for this study.


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The above post is reprinted from materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


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Children's Hospital of Philadelphia. "Drug for erectile dysfunction improves heart function in young heart-disease patients." ScienceDaily. ScienceDaily, 18 November 2009. <www.sciencedaily.com/releases/2009/11/091118101407.htm>.
Children's Hospital of Philadelphia. (2009, November 18). Drug for erectile dysfunction improves heart function in young heart-disease patients. ScienceDaily. Retrieved August 28, 2015 from www.sciencedaily.com/releases/2009/11/091118101407.htm
Children's Hospital of Philadelphia. "Drug for erectile dysfunction improves heart function in young heart-disease patients." ScienceDaily. www.sciencedaily.com/releases/2009/11/091118101407.htm (accessed August 28, 2015).

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