Featured Research

from universities, journals, and other organizations

Forming new brain cells: Key regulatory peptide discovered

Date:
November 29, 2009
Source:
University of Gothenburg
Summary:
The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue.

The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells.

Although the research has been carried out using mice and cultured cells, it could lead to a new medicine for human beings, which could be given to patients who have had a stroke or other disorders that damage or destroy the nerve cells. "Our research findings show that it could be possible to use molecules that are similar to the peptide C3a to boost the formation of nerve cells and stimulate the replacement of nerve cells lost due to injury or illness," says senior lecturer Marcela Pekna who headed the research group at theSahlgrenska Academy.

The peptide C3a is generated through the activation of the complement system, a group of proteins in the blood that is essential for the body's immune defence. "Our research group was the first in the world to show that the complement system also plays an important role in the repair and regeneration of the brain," says Pekna. "This was a surprising discovery that opened up a whole new field of research."

New Nerve Cells

New nerve cells are formed in the brain throughout our lives. The brain's stem cells are formed in the hippocampus and the subventricular zone, an area next to the fluid-filled cavities (lateral ventricles). Stem cells from the subventricular zone mature into nerve cells in the olfactory bulb, but can also migrate out into the brain to replace nerve cells that have been damaged or destroyed. By finding out more about how new nerve cells are formed and what controls their migration, stem cell researchers hope to find new ways of treating stroke, Parkinson's disease and other disorders that result from the nerve cells failing to function as they should.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shinjyo et al. Complement-Derived Anaphylatoxin C3a Regulates In Vitro Differentiation and Migration of Neural Progenitor Cells. Stem Cells, 2009; 27 (11): 2824 DOI: 10.1002/stem.225

Cite This Page:

University of Gothenburg. "Forming new brain cells: Key regulatory peptide discovered." ScienceDaily. ScienceDaily, 29 November 2009. <www.sciencedaily.com/releases/2009/11/091123114807.htm>.
University of Gothenburg. (2009, November 29). Forming new brain cells: Key regulatory peptide discovered. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/11/091123114807.htm
University of Gothenburg. "Forming new brain cells: Key regulatory peptide discovered." ScienceDaily. www.sciencedaily.com/releases/2009/11/091123114807.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins